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Effects of neodymium-yttrium-aluminum garnet (Nd:YAG) pulsed high-intensity laser therapy on full thickness wound healing in an experimental animal model

Title
Effects of neodymium-yttrium-aluminum garnet (Nd:YAG) pulsed high-intensity laser therapy on full thickness wound healing in an experimental animal model
Authors
Hong, Seung EunHong, Mi KiKang, So RaPark, Bo Young
Ewha Authors
강소라박보영홍승은
SCOPUS Author ID
강소라scopus; 박보영scopus; 홍승은scopus
Issue Date
2016
Journal Title
JOURNAL OF COSMETIC AND LASER THERAPY
ISSN
1476-4172JCR Link1476-4180JCR Link
Citation
vol. 18, no. 8, pp. 432 - 437
Keywords
Granulation tissuelaser therapywound healing
Publisher
TAYLOR & FRANCIS INC
Indexed
SCIE; SCOPUS WOS scopus
Abstract
OBJECTIVE: Wound healing can be aided by the use of low- and medium-intensity lasers. The use of pulsed neodymium-doped yttrium aluminum garnet (Nd:YAG) high-intensity laser therapy (HILT) with a 1064-nm wavelength laser provides deeper and more efficient penetration into tissue as it is being less absorbed by chromophores in tissue, e.g., hemoglobin, melanin, and water, thereby enhancing the wound-healing process. In this study, we examined the effect of HILT on wound healing with a Q-switched pulsed Nd:YAG laser in an animal model. DESIGN: Sixty SKH1 hairless male mice (seven weeks old) were randomly divided into four groups according to the amount of laser fluence: control, group 1 (0.8 J/cm2), group 2 (1.6 J/cm2), and group 3 (2.0 J/cm2). Laser treatment was provided to groups 1, 2, and 3 with a 1064-nm Q-switched Nd:YAG laser. Histological analysis was performed with hematoxylin and eosin staining, Masson's Trichrome staining, and Ki-67 staining. RESULTS: Statistically significant increases in the accumulation of collagen fibers, thickness of granulation tissue, and numbers of fibroblasts were observed in group 2 (treated with 1.6 J/cm2) as compared with the control (no laser treatment), group 1 (treated with 0.8 J/cm2), and group 3 (treated with 2.0 J/cm2). CONCLUSION: Nd:YAG HILT stimulated fibroblast proliferation and increased extracellular matrix production. We expect that this therapy could accelerate the wound-healing process.
DOI
10.1080/14764172.2016.1202421
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의학전문대학원 > 의학과 > Journal papers
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