View : 26 Download: 0

Pin1 enhances adipocyte differentiation by positively regulating the transcriptional activity of PPAR gamma

Title
Pin1 enhances adipocyte differentiation by positively regulating the transcriptional activity of PPAR gamma
Authors
Han, YounhoLee, Sung HoBahn, MinjinYeo, Chang-YeolLee, Kwang Youl
Ewha Authors
여창열
SCOPUS Author ID
여창열scopus
Issue Date
2016
Journal Title
MOLECULAR AND CELLULAR ENDOCRINOLOGY
ISSN
0303-7207JCR Link
Citation
vol. 436, no. C, pp. 150 - 158
Keywords
AdipogenesisPin1PPAR gammaERK
Publisher
ELSEVIER IRELAND LTD
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Pin1 is a peptidylprolyl cis/trans isomerase and it has a unique enzymatic activity of catalyzing isomerization of the peptide bond between phospho-serine/threonine and proline. Through the conformational change of its substrates, Pin1 regulates diverse biological processes including adipogenesis. In mouse embryonic fibroblasts and 3T3-L1 preadipocytes, overexpression of Pin1 enhances adipocyte differentiation whereas inhibition of Pin1 activity suppresses it. However, the precise functions of Pin1 during adipogenesis are not clear. In the present study, we investigated the potential targets of Pin1 during adipogenesis. We found that Pin1 interacts directly with and regulates the transcriptional activity of PPAR gamma, a key regulator of adipogenesis. In addition, ERK activity and Ser273 of PPAR gamma, a potential ERK phosphorylation target site, are important for the regulation of PPAR gamma function by Pin1 in 3T3-L1 cells. Taken together our results suggest a novel regulatory mechanism of Pin1 during adipogenesis, in which Pin1 enhances adipocyte differentiation by regulating the function of PPAR gamma. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
DOI
10.1016/j.mce.2016.07.030
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE