Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 신나영 | - |
dc.date.accessioned | 2016-08-29T12:08:45Z | - |
dc.date.available | 2016-08-29T12:08:45Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1353-8020 | - |
dc.identifier.issn | 1873-5126 | - |
dc.identifier.other | OAK-19151 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/231805 | - |
dc.description.abstract | Objective: To explore the microstructural integrity of the optic nerve and its role as a cognitive predictor in patients with de novo Parkinson's disease (PD) using diffusion tensor image-based magnetic resonance scans. Methods: We enrolled 82 patients with de novo PD, 36 patients with drug-induced parkinsonism (DIP), and 36 controls. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were measured on the mid-portion of the intraorbital optic nerve. Using a multivariate analysis of variance with repeated measures, longitudinal changes in cognitive subscores of a comprehensive neuropsychological test were evaluated in PD patients according to optic nerve integrity. Results: The mean FA value in PD was significantly lower (0.552 0.103, p < 0.001) than that in DIP (0.645 +/- 0.099) or the controls (0.689 +/- 0.089), whereas the mean ADC value was significantly higher in the PD group compared to the DIP or control group (p < 0.001). Optic nerve integrity was not associated with parkinsonian motor severity, striatal dopamine transporter activity, olfaction, or baseline cognitive performance in PD patents. In a longitudinal assessment of cognition in PD, the lower FA group showed significant decline in the performance of Clock Drawing Test (F = 3.39, p = 0.038), but no significant differences in the other cognitive subsets. Conclusion: This study demonstrated that microstructural integrity in the optic nerve was distorted in PD patients, and that this nerve integrity might act as a cognitive predictor of visuospatial dysfunction. (C) 2016 Published by Elsevier Ltd. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | Parkinson's disease | - |
dc.subject | Optic nerve | - |
dc.subject | Diffusion tensor image | - |
dc.subject | Cognition | - |
dc.title | Optic nerve integrity as a visuospatial cognitive predictor in Parkinson's disease | - |
dc.type | Article | - |
dc.relation.volume | 31 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 41 | - |
dc.relation.lastpage | 45 | - |
dc.relation.journaltitle | PARKINSONISM & RELATED DISORDERS | - |
dc.identifier.doi | 10.1016/j.parkreldis.2016.06.020 | - |
dc.identifier.wosid | WOS:000386320100007 | - |
dc.identifier.scopusid | 2-s2.0-84979665800 | - |
dc.author.google | Lee, Jae Jung | - |
dc.author.google | Shin, Na-Young | - |
dc.author.google | Lee, Yoonju | - |
dc.author.google | Lee, Seung-Koo | - |
dc.author.google | Sohn, Young H. | - |
dc.author.google | Lee, Phil Hyu | - |
dc.contributor.scopusid | 신나영(56363572300) | - |
dc.date.modifydate | 20220119162742 | - |