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Association between Vitamin D Deficiency and Anemia in Patients with End-Stage Renal Disease: A Cross-Sectional Study

Title
Association between Vitamin D Deficiency and Anemia in Patients with End-Stage Renal Disease: A Cross-Sectional Study
Authors
Kim, Yung LyKim, HyunwookKwon, Young EunRyu, Dong-RyeolLee, Mi JungPark, Kyung SookRyu, Han JakPark, Jung TakOh, Hyung JungHan, Seung HyeokYoo, Tae-HyunKang, Shin-Wook
Ewha Authors
류동열
SCOPUS Author ID
류동열scopus
Issue Date
2016
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
0513-5796JCR Link1976-2437JCR Link
Citation
vol. 57, no. 5, pp. 1159 - 1164
Keywords
Vitamin D deficiencyanemiaend-stage renal disease
Publisher
YONSEI UNIV COLL MEDICINE
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Purpose: Despite new treatment strategies, anemia remains the most prevalent complication in patients with end-stage renal disease (ESRD). We investigated whether 25-hydroxyvitamin D [25(OH) D3] deficiency was associated with anemia in ESRD patients. Materials and Methods: We reviewed the medical records of 410 ESRD patients who had undergone renal transplantation (RTx) at Yonsei University Health System and who had 25(OH) D3 levels measured at the time of RTx. Patients were divided into two groups based on baseline 25(OH) D3 concentrations: group 1, 25(OH) D3 levels < 10 ng/mL; and group 2, 25(OH) D3 levels >= 10 ng/mL. Results: Using multivariate regression models, 25(OH) D3, age, and erythrocyte-stimulating agent (ESA) dose were found to be significantly associated with hemoglobin (Hb) levels [25(OH) D3: beta= 0.263, p< 0.001; age: beta= 0.122, p= 0.010; ESA dose: beta=-0.069, p= 0.005]. In addition, logistic regression analysis revealed that patients in group 1 had a significantly higher risk for developing anemia (Hb level < 10 g/dL) compared to group 2 patients, even after adjusting for potential risk factors for anemia (odds ratio= 3.857; confidence interval= 1.091-13.632; p= 0.036). Conclusion: 25(OH) D3 deficiency was significantly associated with anemia in patients with ESRD. Randomized controlled trials are needed to determine whether vitamin D supplementation can improve anemia in these patients.
DOI
10.3349/ymj.2016.57.5.1159
Appears in Collections:
의과대학 > 의학과 > Journal papers
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