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Expression patterns of GATA3 and the androgen receptor are strongly correlated in patients with triple-negative breast cancer

Title
Expression patterns of GATA3 and the androgen receptor are strongly correlated in patients with triple-negative breast cancer
Authors
Kim, SewhaMoon, Byung-InLim, WoosungPark, SanghuiCho, Min SunSung, Sun Hee
Ewha Authors
성순희문병인조민선임우성박성희박상희
SCOPUS Author ID
성순희scopus; 문병인scopus; 조민선scopus; 임우성scopus; 박성희scopus; 박상희scopus
Issue Date
2016
Journal Title
HUMAN PATHOLOGY
ISSN
0046-8177JCR Link1532-8392JCR Link
Citation
vol. 55, pp. 190 - 195
Keywords
Triple-negative breast carcinomaMolecular subtypeGATA3Androgen receptorImmunohistochemistry
Publisher
W B SAUNDERS CO-ELSEVIER INC
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
GATA-binding protein 3 (GATA3) is a diagnostically useful immunohistochemical marker of breast cancer. Because of its strong association with estrogen receptor expression, GATA3 has markedly reduced sensitivity in triple-negative breast cancer (TNBC). We constructed a tissue microarray using a large series of TNBCs and evaluated GATA3 expression by TNBC subtype as defined by surrogate immunohistochemical markers. A total of 205 TNBCs were classified into cancers of the molecular apocrine type (n = 23, 11.2%), claudin-low type (n = 21, 10.2%), basal-like type (n = 91, 44.4%), mixed type (n = 62, 30.2%), and null type (n = 8, 3.9%). The GATA3 scores (staining intensity x proportion) were categorized as negative (0), focally positive (1-10), or positive (11-300). GATA3 staining was negative in 153 cancers (74.6%), focally positive in 11 (5.4%), and positive in 41 (20.0%). The rate of focal positivity or positivity for GATA3 was significantly higher in the molecular apocrine type (73.9%, 17/23) than in other types of TNBCs (P=.001). The mean GATA3 score of molecular apocrine type TNBC was significantly higher than that of the other types (P=.001) and differed significantly between androgen receptor (AR) positive and AR-negative TNBCs (P<.001). In conclusion, GATA3 expression was correlated strongly with AR positive, molecular apocrine type TNBCs. Co-expression of AR and GATA3 is a specific feature of molecular apocrine type TNBC, which may serve as a diagnostic aid for cancer of unknown primary. (C) 2016 Published by Elsevier Inc.
DOI
10.1016/j.humpath.2016.04.013
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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