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Changes in serum metabolites with the stage of chronic kidney disease: Comparison of diabetes and non-diabetes

Title
Changes in serum metabolites with the stage of chronic kidney disease: Comparison of diabetes and non-diabetes
Authors
Lee, JueunChoi, Ji-YoungKwon, Yong-KookLee, DoohaeJung, Hee-YeonRyu, Hye-MyungCho, Jang-HeeRyu, Do HyunKim, Yong-LimHwang, Geum-Sook
Ewha Authors
황금숙
SCOPUS Author ID
황금숙scopusscopus
Issue Date
2016
Journal Title
CLINICA CHIMICA ACTA
ISSN
0009-8981JCR Link1873-3492JCR Link
Citation
vol. 459, pp. 123 - 131
Keywords
Chronic kidney diseaseDiabetes mellitusMetabolite profilingNuclear magnetic resonance spectroscopy
Publisher
ELSEVIER SCIENCE BV
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background: The renal dysfunction of chronic kidney disease (CKD) alters serum metabolite levels, but it is not clear how diabetes mellitus (DM) affects the metabolic changes in CKD. Methods: Serum metabolites from pre-dialysis CKD patients (n = 291) with or without DM and from healthy controls (n = 56) was measured using nuclear magnetic resonance. Results: Initial principal components analysis and partial least squares-discriminant analysis score plots segregated the CKD patients according to CKD stage and separated DM from non-DM patients. In the CKD patients, associations were seen with clinical characteristics, hyperglycemia, altered amino acid metabolism, accumulated uremic toxins, and dyslipidemia. Of interest, diabetes more strongly affected the metabolic signature during early stage CKD. Furthermore, serum metabolite profiles were successfully applied to the PIS regression model to predict the estimated glomerular filtration rate. The R-2 values from the PLS models for CKD patients with DM were higher than those for CKD without DM. Conclusions: Metabolomics is useful clinically for providing a metabolic signature that is associated with the CKD phenotype and diabetes more seriously affects patients with early stage CKD compared to those with advanced CKD. (C) 2016 Elsevier B.V. All rights reserved.
DOI
10.1016/j.cca.2016.05.018
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자연과학대학 > 화학·나노과학전공 > Journal papers
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