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Neurocognitive changes and their neural correlates in patients with type 2 diabetes mellitus

Title
Neurocognitive changes and their neural correlates in patients with type 2 diabetes mellitus
Authors
Lee J.H.Choi Y.Jun C.Hong Y.S.Cho H.B.Kim J.E.Lyoo I.K.
Ewha Authors
홍영선김지은류인균이정현전찬수
SCOPUS Author ID
홍영선scopus; 김지은scopus; 류인균scopus
Issue Date
2014
Journal Title
Endocrinology and Metabolism
ISSN
2093-596XJCR Link
Citation
vol. 29, no. 2, pp. 112 - 121
Keywords
Cognition disordersDementiaDiabetes mellitusHyperglycemiaHypoglycemiaMagnetic resonance imagingMagnetic resonance spectroscopyType 2
Publisher
Korean Endocrine Society
Indexed
SCOPUS; KCI scopus
Abstract
As the prevalence and life expectancy of type 2 diabetes mellitus (T2DM) continue to increase, the importance of effective detection and intervention for the complications of T2DM, especially neurocognitive complications including cognitive dysfunction and dementia, is receiving greater attention. T2DM is thought to influence cognitive function through an as yet unclear mechanism that involves multiple factors such as hyperglycemia, hypoglycemia, and vascular disease. Recent developments in neuroimaging methods have led to the identification of potential neural correlates of T2DM-related neurocognitive changes, which extend from structural to functional and metabolite alterations in the brain. The evidence indicates various changes in the T2DM brain, including global and regional atrophy, white matter hyperintensity, altered functional connectivity, and changes in neurometabolite levels. Continued neuroimaging research is expected to further elucidate the underpinnings of cognitive decline in T2DM and allow better diagnosis and treatment of the condition. © 2014 Korean Endocrine Society.
DOI
10.3803/EnM.2014.29.2.112
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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