Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤혜전 | * |
dc.date.accessioned | 2016-08-29T12:08:57Z | - |
dc.date.available | 2016-08-29T12:08:57Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 0363-9762 | * |
dc.identifier.issn | 1536-0229 | * |
dc.identifier.other | OAK-18835 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/231651 | - |
dc.description.abstract | Purpose: We performed pretreatment angiogenesis imaging (Ga-68-NOTA-arginyl-glycyl-aspartic acid [RGD] PET/CT) to compare its prognostic value to dynamic contrast-enhanced (DCE) MRI in breast cancer patients. Methods: Forty-four female patients with stage II or III breast cancer (aged 47.3 +/- 8.1 years) were prospectively enrolled and underwent Ga-68-NOTA-RGD PET/CT and DCE-MRI imaging. All patients received neoadjuvant chemotherapy and underwent surgery. With pretreatment Ga-68-NOTA-RGD PET/CT, SUVmax of the tumor in the torso (-T) and regional (-R) images were measured. With pretreatment DCE-MRI, the largest diameter of the tumor and maximum enhancement index (EImax; EImax = [highest signal / baseline signal] - 1) of the tumor were assessed. Results: Ten patients (22.7%) were found to have breast cancer recurrence after 17.9 +/- 11.2 months. The SUVmax-R (P = 0.017, cutoff >2.79) of Ga-68-NOTA-RGD PET/CT, the largest diameter of tumor (P = 0.017, cutoff >6.3 cm), and the EImax (P = 0.008, cutoff >5.38) of DCE-MRI showed significant results by univariate analysis. The 3-year disease-free survival of SUVmax-R was 91.7% versus 59.1% by Kaplan-Meier analysis (hazard ratio, 5.379). Multivariable analysis demonstrated that SUVmax-R with tumor diameter or EImax were the significant parameters. In addition, the combined parameters of SUVmax-R and EImax revealed better predictive value for prediction of breast cancer recurrence (75.0%) than each parameter of SUVmax-R (64.2%) and EImax (68.7%). Conclusions: Increased angiogenic activity of regional Ga-68-NOTA-RGD PET/CT (SUVmax-R) can be an early prognostic marker for the prediction of breast cancer recurrence. | * |
dc.language | English | * |
dc.publisher | LIPPINCOTT WILLIAMS & | * |
dc.publisher | WILKINS | * |
dc.subject | Ga-68 | * |
dc.subject | angiogenesis | * |
dc.subject | breast cancer | * |
dc.subject | integrin | * |
dc.subject | RGD | * |
dc.title | Prognostic Value of Ga-68-NOTA-RGD PET/CT for Predicting Disease-Free Survival for Patients With Breast Cancer Undergoing Neoadjuvant Chemotherapy and Surgery A Comparison Study With Dynamic Contrast Enhanced MRI | * |
dc.type | Article | * |
dc.relation.issue | 8 | * |
dc.relation.volume | 41 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 614 | * |
dc.relation.lastpage | 620 | * |
dc.relation.journaltitle | CLINICAL NUCLEAR MEDICINE | * |
dc.identifier.doi | 10.1097/RLU.0000000000001274 | * |
dc.identifier.wosid | WOS:000379666200012 | * |
dc.identifier.scopusid | 2-s2.0-84973345451 | * |
dc.author.google | Kim, Yong-il | * |
dc.author.google | Yoon, Hai-Jeon | * |
dc.author.google | Paeng, Jin Chul | * |
dc.author.google | Cheon, Gi Jeong | * |
dc.author.google | Lee, Dong Soo | * |
dc.author.google | Chung, June-Key | * |
dc.author.google | Kim, E. Edmund | * |
dc.author.google | Moon, Woo Kyung | * |
dc.author.google | Kang, Keon Wook | * |
dc.contributor.scopusid | 윤혜전(47161772300) | * |
dc.date.modifydate | 20240222164135 | * |