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The TRPCs, Orais and STIMs in ER/PM junctions

Title
The TRPCs, Orais and STIMs in ER/PM junctions
Authors
Shin D.M.Son A.Park S.Kim M.S.Ahuja M.Muallem S.
Ewha Authors
박성희
SCOPUS Author ID
박성희scopus
Issue Date
2016
Journal Title
Advances in Experimental Medicine and Biology
ISSN
0065-2598JCR Link
Citation
Advances in Experimental Medicine and Biology vol. 898, pp. 47 - 66
Keywords
ER/PM junctionOraiSTIM1STIM2TRPC channels
Publisher
Springer New York LLC
Indexed
SCIE; SCOPUS scopus
Document Type
Article
Abstract
The Ca2+ second messenger is initiated at ER/PM junctions and propagates into the cell interior to convey the receptor information. The signal is maintained by Ca2+ influx across the plasma membrane through the Orai and TRPC channels. These Ca2+ influx channels form complexes at ER/PM junctions with the ER Ca2+ sensor STIM1, which activates the channels. The function of STIM1 is modulated by other STIM isoforms like STIM1L, STIM2 and STIM2.1/STIM2β and by SARAF, which mediates the Ca2+ -dependent inhibition of Orai channels. The ER/PM junctions are formed at membrane contact sites by tethering proteins that generate several types of ER/PM junctions, such as PI(4,5)P2 -poor and PI(4,5) P2 -rich domains. This chapter discusses several properties of the TRPC channels, the Orai channels and the STIMs, their key interacting proteins and how interaction of the STIMs with the channels gates their activity. The chapter closes by highlighting open questions and potential future directions in this field. © Springer International Publishing Switzerland 2016.
DOI
10.1007/978-3-319-26974-0_3
Appears in Collections:
의과대학 > 의학과 > Journal papers
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