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Black cohosh inhibits 17 beta-estradiol-induced cell proliferation of endometrial adenocarcinoma cells

Title
Black cohosh inhibits 17 beta-estradiol-induced cell proliferation of endometrial adenocarcinoma cells
Authors
Park, So YunKim, Hee JaLee, Sa RaChoi, Youn-HeeJeong, KyungahChung, Hyewon
Ewha Authors
정혜원정경아최윤희이사라
SCOPUS Author ID
정혜원scopus; 정경아scopus; 최윤희scopus; 이사라scopus
Issue Date
2016
Journal Title
GYNECOLOGICAL ENDOCRINOLOGY
ISSN
0951-3590JCR Link1473-0766JCR Link
Citation
vol. 32, no. 10, pp. 840 - 843
Keywords
Endometriumestrogenmenopauseuterus
Publisher
TAYLOR & FRANCIS LTD
Indexed
SCIE; SCOPUS WOS scopus
Abstract
This study was conducted to investigate the effect of black cohosh (BC) extract on the proliferation and apoptosis of Ishikawa cells. Ishikawa human endometrial adenocarcinoma cells were treated with or without BC (1, 5, 10 and 25 mu M) and cell proliferation and cytotoxicity were measured by CCK-8 assays and flow cytometry analysis. Additionally, Ishikawa cells were treated with 17 beta-estradiol (E2), E2 + progesterone and E2 + BC (5 and 10 mM) and the effect of BC and progesterone on E2-induced cell proliferation was analyzed. BC decreased the proliferation of Ishikawa cells at a dose-dependent rate compared with the control group (p < 0.05). The proliferation of Ishikawa cells increased in the presence of E2, whereas the subsequent addition of progesterone or BC decreased proliferation to the level of the control group (p < 0.05). The inhibitory effect of BC on E2-induced cell proliferation was greater than the inhibitory effect of progesterone. In conclusion, BC induces apoptosis in Ishikawa cells and suppresses E2-induced cell proliferation in Ishikawa cells. BC could be considered a candidate co-treatment agent of estrogen-dependent tumors, especially those involving endometrial cells.
DOI
10.1080/09513590.2016.1188372
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의학전문대학원 > 의학과 > Journal papers
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