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A case of disseminated multidrug-resistant tuberculosis involving the brain

Title
A case of disseminated multidrug-resistant tuberculosis involving the brain
Authors
Jung E.K.Chang J.Y.Lee Y.P.Chung M.K.Seo E.K.Koo H.S.Choi H.J.
Ewha Authors
구혜수최희정서의교
SCOPUS Author ID
구혜수scopus; 최희정scopus; 서의교scopus
Issue Date
2016
Journal Title
Infection and Chemotherapy
ISSN
2093-2340JCR Link
Citation
vol. 48, no. 1, pp. 41 - 46
Keywords
Central nervous systemMultidrug-resistantMycobacterium tuberculosisPulmonaryTuberculosis
Publisher
Korean Society for Chemotherapy
Indexed
SCOPUS scopus
Abstract
We report a case of a 23-year-old female immigrant from China who was diagnosed with multidrug-resistant tuberculosis affecting her lung and brain, resistant to the standard first-line therapeutics and streptomycin. She was treated with prothionamide, moxifloxacin, cycloserine, and kanamycin. However, her headache and brain lesion worsened. After the brain biopsy, the patient was confirmed with intracranial tuberculoma. Linezolid was added to intensify the treatment regimen, and steroid was added for the possibility of paradoxical response. Kanamycin was discontinued 6 months after initiation of the treatment; she was treated for 18 months with susceptible drugs and completely recovered. To our knowledge, this case is the first multidrug- resistant tuberculosis that disseminated to the brain in Korea. ©2016 by The Korean Society of Infectious Diseases.
DOI
10.3947/ic.2016.48.1.41
Appears in Collections:
의과대학 > 의학과 > Journal papers
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