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Is the presence of IgG4+cells within urothelial carcinomas of the renal pelvis that contain rhabdoid and sarcomatoid features associated with IgG4-related diseases?

Title
Is the presence of IgG4+cells within urothelial carcinomas of the renal pelvis that contain rhabdoid and sarcomatoid features associated with IgG4-related diseases?
Authors
Choi, Sun YoungPark, Sanghui
Ewha Authors
최선영박상희
SCOPUS Author ID
최선영scopus; 박상희scopus
Issue Date
2016
Journal Title
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
ISSN
1936-2625JCR Link
Citation
vol. 9, no. 3, pp. 4033 - 4037
Keywords
IgG4plasma cellurothelial carcinomarhabdoid
Publisher
E-CENTURY PUBLISHING CORP
Indexed
SCIE; SCOPUS WOS scopus
Abstract
A 69-year-old male underwent nephrectomy after presenting with a renal mass, as visualized through imaging. Histologic evaluation of the specimen revealed a papillary urothelial carcinoma (UC) in the renal pelvis with infiltration into the renal parenchyma that showed sarcomatoid and rhabdoid features; these features are typically associated with mixed inflammatory infiltrate, storiform fibrosis, and obliterative phlebitis, which is reminiscent of IgG4-related disease (IgG4-RD). Immunohistochemical labeling for IgG4 plasma cells showed that there were > 50 cells in a single high-power field and the ratio of IgG4/IgG was > 40%; these results are consistent with a diagnosis of IgG4-RD. Herein, we describe the first case of UC that has both sarcomatoid and rhabdoid features and high proportions of IgG4+ plasma cells.
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의학전문대학원 > 의학과 > Journal papers
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