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Mitochondria-Targeted Reaction-Based Fluorescent Probe for Hydrogen Sulfide
- Mitochondria-Targeted Reaction-Based Fluorescent Probe for Hydrogen Sulfide
- Pak Y.L.; Li J.; Ko K.C.; Kim G.; Lee J.Y.; Yoon J.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- Analytical Chemistry
- vol. 88, no. 10, pp. 5476 - 5481
- American Chemical Society
- SCI; SCIE; SCOPUS
- In this study, we developed a turn-on mitochondria-targeting hydrogen sulfide, "probe 1", based on the selective thiolysis of 7-nitro-1,2,3-benzoxadiazole amine moiety attached to the piperazine-based naphthalimide scaffold. Probe 1 exhibited excellent properties with 68-fold fluorescence enhancement, a low detection limit (2.46 μM), a low cytotoxicity, and a good selectivity toward hydrogen sulfide. The success of intracellular imaging indicated that probe 1 could be used in further applications for the investigation of biological functions and pathological roles of H2S in living systems. © 2016 American Chemical Society.
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