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Mitochondria-Targeted Reaction-Based Fluorescent Probe for Hydrogen Sulfide

Title
Mitochondria-Targeted Reaction-Based Fluorescent Probe for Hydrogen Sulfide
Authors
Pak Y.L.Li J.Ko K.C.Kim G.Lee J.Y.Yoon J.
Ewha Authors
윤주영
SCOPUS Author ID
윤주영scopus
Issue Date
2016
Journal Title
Analytical Chemistry
ISSN
0003-2700JCR Link
Citation
vol. 88, no. 10, pp. 5476 - 5481
Publisher
American Chemical Society
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
In this study, we developed a turn-on mitochondria-targeting hydrogen sulfide, "probe 1", based on the selective thiolysis of 7-nitro-1,2,3-benzoxadiazole amine moiety attached to the piperazine-based naphthalimide scaffold. Probe 1 exhibited excellent properties with 68-fold fluorescence enhancement, a low detection limit (2.46 μM), a low cytotoxicity, and a good selectivity toward hydrogen sulfide. The success of intracellular imaging indicated that probe 1 could be used in further applications for the investigation of biological functions and pathological roles of H2S in living systems. © 2016 American Chemical Society.
DOI
10.1021/acs.analchem.6b00956
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자연과학대학 > 화학·나노과학전공 > Journal papers
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