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Age-related reduction of antibody response against the human endogenous retrovirus K envelope in women

Title
Age-related reduction of antibody response against the human endogenous retrovirus K envelope in women
Authors
Kim H.J.Moon B.-I.Lee J.W.Kim S.C.Kim H.-J.
Ewha Authors
김승철문병인이준우
SCOPUS Author ID
김승철scopus; 문병인scopus; 이준우scopus
Issue Date
2016
Journal Title
Oncotarget
ISSN
1949-2553JCR Link
Citation
vol. 7, no. 14, pp. 17327 - 17337
Keywords
AgeBreast cancerCervical cancerEnvelopeGerotargetHuman endogenous retrovirus K
Publisher
Impact Journals LLC
Indexed
SCIE; SCOPUS WOS scopus
Abstract
In the present study, the correlation between the antibody response against human endogenous retrovirus K (HERV-K) envelope and human age was investigated. Antibody levels were compared in groups in their 20s (n = 25), 30s (n = 39), 40s (n = 68), 50s (n = 32), and 60s and over (n = 25), which included healthy individuals and breast cancer and/or cervical cancer patients. It appeared that both IgM and IgG responses against the HERV-K envelope fell with increasing age. There were no differences in anti-HERV-K envelope antibody levels between healthy individuals and cancer patients. Therefore, our results indicated that the anti-HERV-K antibody levels cannot be considered as cancer-specific marker. Also, IgG1 appeared to be the predominant subtype in the reduction of the IgG response by age. Receiver operating characteristic curves of anti-HERV-K envelope IgM levels indicated that the groups of people in their 20s or 30s could be distinguished from those in their 40s, 50s or 60s and over with satisfactory sensitivity and specificity. These findings indicate that the serum antibody level of HERV-K envelope is a critical parameter reflecting person's age.
DOI
10.18632/oncotarget.7307
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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