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Factors contributing to the preference of Korean patients with Crohn's disease when selecting an anti-tumor necrosis factor agent (Choice study)

Title
Factors contributing to the preference of Korean patients with Crohn's disease when selecting an anti-tumor necrosis factor agent (Choice study)
Authors
Kim E.S.Kim K.O.Jang B.I.Lee C.K.Kim H.J.Lee K.-M.Kim Y.S.Eun C.S.Jung S.-A.Yang S.-K.Lee J.Kim T.-O.Jung Y.Seo G.S.Yoon S.M.
Ewha Authors
정성애
SCOPUS Author ID
정성애scopus
Issue Date
2016
Journal Title
Gut and Liver
ISSN
1976-2283JCR Link
Citation
vol. 10, no. 3, pp. 391 - 398
Keywords
AdalimumabCrohn diseaseInfliximabPreference
Publisher
Joe Bok Chung
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Background/Aims: Two comparable anti-tumor necrosis factor (TNF) agents with different routes of administration (intravenous [iv] infliximab [IFX] vs subcutaneous [sc] adalimumab [ADA]) are available for patients with Crohn's disease (CD) in Korea. This study aimed to identify the preferences of Korean CD patients for a specific anti-TNF agent and the factors contributing to the decision. Methods: A prospective survey was performed among anti-TNF-naive CD patients in 10 tertiary referral hospitals. A 16-item questionnaire addressed patient preferences and the factors contributing to the decision in favor of a particular anti-TNF agent. A logistic regression was conducted to assess predictive factors for ADA preference. Results: Overall, 189 patients (139 males; mean age, 32.47±11.71 years) completed the questionnaire. IFX and ADA were preferred by 63.5% (120/189) and 36.5% (69/189) of patients, respectively. The most influential reason for choosing IFX was 'doctor's presence' (68.3%, 82/120), and ADA was "easy to use" (34.8%, 24/69). Amid various clinicodemographic data, having a > 60-minute travel time to the hospital was a significant independent predictive factor for ADA preference. Conclusions: A large number of anti-TNF-naive Korean patients with CD preferred anti-TNFs with an iv route of administration. The reassuring effect of a doctor's presence might be the main contributing factor for this decision. © This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License.
DOI
10.5009/gnl15126
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의학전문대학원 > 의학과 > Journal papers
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