View : 31 Download: 0

The association of thyroid hormones and blood pressure in euthyroid preadolescents

Title
The association of thyroid hormones and blood pressure in euthyroid preadolescents
Authors
Park B.H.Baik S.J.Lee H.A.Hong Y.S.Kim H.S.Park H.
Ewha Authors
김혜순박혜숙홍영선박보현이혜아
SCOPUS Author ID
김혜순scopus; 박혜숙scopus; 홍영선scopus; 박보현scopus; 이혜아scopus
Issue Date
2016
Journal Title
Journal of Pediatric Endocrinology and Metabolism
ISSN
0334-018XJCR Link
Citation
vol. 29, no. 4, pp. 459 - 464
Keywords
blood pressurechildrenthyroid hormone
Publisher
Walter de Gruyter GmbH
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background: Hypertension is the leading cause of cardiovascular disease worldwide, and both high and low blood pressures are associated with various chronic diseases. Thyroid hormones have profound effects on cardiovascular function, including on blood pressure. Recent studies have shown that childhood hypertension can lead to adult hypertension. Therefore, adequate blood pressure control is important from early life. Employing a life-course approach, we aimed to investigate the association between thyroid hormones and blood pressure in children. Methods: A total of 290 children from the Ewha Woman's University Hospital birth cohort participated in a preadolescent check-up program. We assessed the levels of serum thyroid-stimulating hormone (TSH) and free thyroxine (FT4) and the blood pressure status in these children. Thyroid hormone concentrations were measured using an electro-chemiluminescence immunoassay (ECLIA), and hypertension was defined according to the guideline of the Korea Centers for Disease Control and Prevention. Results: The sex-, age-, and height-adjusted prevalence of hypertension was 27.0% in the present study. On regression analysis, serum FT4 showed significantly negative association with diastolic blood pressure (DBP; β=-8.24, 95% CI: -14.19-2.28, p=0.007). However, these relationships were not significant after adjustment for sex, age, and current body mass index. The levels of serum TSH showed no relationship with mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) after adjustment. No significant differences in serum TSH and FT4 levels according to hypertension status were found. Conclusions: These findings suggest that thyroid hormone is not independently associated with increased blood pressure in euthyroid preadolescents. © 2016 by De Gruyter.
DOI
10.1515/jpem-2015-0084
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE