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Diagnosis and treatment of nontuberculous mycobacterial lung disease: Clinicians' perspectives

Title
Diagnosis and treatment of nontuberculous mycobacterial lung disease: Clinicians' perspectives
Authors
Ryu Y.J.Koh W.-J.Daley C.L.
Ewha Authors
류연주
SCOPUS Author ID
류연주scopus
Issue Date
2016
Journal Title
Tuberculosis and Respiratory Diseases
ISSN
1738-3536JCR Link
Citation
vol. 79, no. 2, pp. 74 - 84
Keywords
MycobacteriumMycobacterium avium complexMycobacterium kansasiiNontuberculous mycobacteria
Publisher
Korean National Tuberculosis Association
Indexed
SCOPUS; KCI scopus
Abstract
Nontuberculous mycobacteria (NTM) are emerging pathogens that affect both immunocompromised and immunocompetent patients. The incidence and prevalence of NTM lung disease are increasing worldwide and rapidly becoming a major public health problem. For the diagnosis of NTM lung disease, patients suspected to have NTM lung disease are required to meet all clinical and microbiologic criteria. The development of molecular methods allows the characterization of new species and NTM identification at a subspecies level. Even after the identification of NTM species from respiratory specimens, clinicians should consider the clinical significance of such findings. Besides the limited options, treatment is lengthy and varies by species, and therefore a challenge. Treatment may be complicated by potential toxicity with discouraging outcomes. The decision to start treatment for NTM lung disease is not easy and requires careful individualized analysis of risks and benefits. Clinicians should be alert to those unique aspects of NTM lung disease concerning diagnosis with advanced molecular methods and treatment with limited options. Current recommendations and recent advances for diagnosis and treatment of NTM lung disease are summarized in this article. Copyright © 2016 The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.
DOI
10.4046/trd.2016.79.2.74
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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