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Reduced immunoreactivities of B-type natriuretic peptide in pulmonary arterial hypertension rats after ranolazine treatmen

Title
Reduced immunoreactivities of B-type natriuretic peptide in pulmonary arterial hypertension rats after ranolazine treatmen
Authors
Lee J.C.Kim K.C.Choe S.Y.Hong Y.M.
Ewha Authors
홍영미김관창
SCOPUS Author ID
홍영미scopus; 김관창scopus
Issue Date
2016
Journal Title
Anatomy and Cell Biology
ISSN
2093-3665JCR Link
Citation
vol. 49, no. 1, pp. 7 - 14
Keywords
B-type natriuretic peptideHeartPulmonary artery hypertensionRanolazineRight ventricles
Publisher
Korean Association of Anatomists
Indexed
SCOPUS; KCI scopus
Abstract
Pulmonary arterial hypertension (PAH) is a severe pulmonary vascular disease characterized by sustained increase in the pulmonary arterial pressure and excessive thickening and remodeling of the distal small pulmonary arteries. During disease progression, structural remodeling of the right ventricular (RV) impairs pump function, creates pro-arrhythmic substrates and triggers for arrhythmias. Notably, RV failure and lethal arrhythmias are major contributors to cardiac death in PAH that are not directly addressed by currently available therapies. Ranolazine (RAN) is an anti-anginal, anti-ischemic drug that has cardioprotective effects of heart dysfunction. RAN also has anti-arrhythmic effects due to inhibition of the late sodium current in cardiomyocytes. Therefore, we hypothesized that RAN could reduce the mal-adaptive structural remodeling of the RV, and prevent triggered ventricular arrhythmias in the monocrotaline-induced rat model of PAH. RAN reduced ventricular hypertrophy, reduced levels of B-type natriuretic peptide, and decreased the expression of fibrosis. In addition, RAN prevented cardiovascular death in rat model of PAH. These results support the notion that RAN can improve the functional properties of the RV, highlighting its potential benefits in the setting of heart impairment. © 2016. Anatomy & Cell Biology.
DOI
10.5115/acb.2016.49.1.7
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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