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Acute hyperammonemic encephalopathy after 5-fluorouracil based chemotherapy
- Acute hyperammonemic encephalopathy after 5-fluorouracil based chemotherapy
- Yi, Hee Jung; Hong, Kyung Sook; Moon, Nara; Chung, Soon Sup; Lee, Ryung-Ah; Kim, Kwang Ho
- Ewha Authors
- 김광호; 이령아; 정순섭; 홍경숙; 문나라
- SCOPUS Author ID
- 김광호; 이령아; 정순섭; 홍경숙
- Issue Date
- Journal Title
- ANNALS OF SURGICAL TREATMENT AND RESEARCH
- 2288-6575; 2288-6796
- vol. 90, no. 3, pp. 179 - 182
- Colorectal neoplasma; 5-Fluorouracil; Hyperammonemia; Metabolic brain diseases
- KOREAN SURGICAL SOCIETY
- SCIE; SCOPUS; KCI
- 5-Fluorouracil (5-FU) based chemotherapy has been commonly used to treat metastatic or advanced colon cancer as an adjuvant chemotherapy. Although the side effects of 5-FU such as gastrointestinal problems and neutropenia and thrombocytopenia are common, not many cases of 5-FU related encephalopathy are reported. Hyperammonemic encephalopathy is a rare central nervous system toxicity following 5-FU chemotherapy manifesting as altered mental status with elevated ammonia levels with no radiologic abnormality. We report one case of 5-FU induced hyperammonemic encephalopathy occurring after Folfox4 (oxaliplatin, folinic acid and 5-fluorouracil) chemotherapy in a colon cancer patient who presented with confused mental status soon after the chemotherapy and review the 5-FU related encephalopathy.
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