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dc.contributor.author박경란-
dc.date.accessioned2016-08-29T12:08:43Z-
dc.date.available2016-08-29T12:08:43Z-
dc.date.issued2016-
dc.identifier.issn1598-2998-
dc.identifier.otherOAK-18483-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/231498-
dc.description.abstractPurpose This study analyzed the outcomes of patients with resected extrahepatic bile duct cancer (EHBDC) in order to clarify the role of adjuvant treatments in these patients. Materials and Methods A total of 336 patients with EHBDC who underwent curative resection between 2001 and 2010 were analyzed retrospectively. The treatment types were as follows: Surgery alone (n=168), surgery with chemotherapy (CTx, n=90), surgery with radiotherapy (RT) alone (n=29), and surgery with chemoradiotherapy (CRT, n=49). Results The median follow-up period was 63 months. The 5-year rates of locoregional failure-free survival (LRFFS), distant metastasis-free survival (DMFS), progression-free survival (PFS), and overall survival (OS) for all patients were 56.5%, 59.7%, 36.6%, and 42.0%, respectively. In multivariate analysis, surgery with RT and CRT was a significant prognostic factor for LRFFS, and surgery with CTx was a significant prognostic factor for DMFS, and surgery with CTx, RT, and CRT was a significant prognostic factor for PFS (p < 0.05). Surgery with CTx and CRT showed association with superior OS (p < 0.05), and surgery with RT had marginal significance (p=0.078). In multivariate analysis of the R1 resection patients, surgery with CRT showed significant association with OS (p < 0.05). Conclusion Adjuvant RT and CTx may be helpful in improving clinical outcomes of patients with resected EHBDC who have a high risk of disease recurrence, particularly R1 resection patients. Conduct of additional prospective, larger-scale studies will be required in order to confirm the benefit of adjuvant RT and CTx in these patients. © 2016 by the Korean Cancer Association.-
dc.languageEnglish-
dc.publisherKorean Cancer Association-
dc.subjectAdjuvant radiotherapy-
dc.subjectBiliary tract neoplasms-
dc.subjectCholangiocarcinoma-
dc.subjectDrug therapy-
dc.subjectExtrahepatic bile duct cancer-
dc.subjectSurvival-
dc.titleSurgery alone versus surgery followed by chemotherapy and radiotherapy in resected extrahepatic bile duct cancer: Treatment outcome analysis of 336 patients-
dc.typeArticle-
dc.relation.issue2-
dc.relation.volume48-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage583-
dc.relation.lastpage595-
dc.relation.journaltitleCancer Research and Treatment-
dc.identifier.doi10.4143/crt.2015.091-
dc.identifier.wosidWOS:000374197200019-
dc.identifier.scopusid2-s2.0-84963828943-
dc.author.googleIm J.H.-
dc.author.googleSeong J.-
dc.author.googleLee I.J.-
dc.author.googlePark J.S.-
dc.author.googleYoon D.S.-
dc.author.googleKim K.S.-
dc.author.googleLee W.J.-
dc.author.googlePark K.R.-
dc.contributor.scopusid박경란(14040340300)-
dc.date.modifydate20180104081001-
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