Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 박경란 | - |
dc.date.accessioned | 2016-08-29T12:08:43Z | - |
dc.date.available | 2016-08-29T12:08:43Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.other | OAK-18483 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/231498 | - |
dc.description.abstract | Purpose This study analyzed the outcomes of patients with resected extrahepatic bile duct cancer (EHBDC) in order to clarify the role of adjuvant treatments in these patients. Materials and Methods A total of 336 patients with EHBDC who underwent curative resection between 2001 and 2010 were analyzed retrospectively. The treatment types were as follows: Surgery alone (n=168), surgery with chemotherapy (CTx, n=90), surgery with radiotherapy (RT) alone (n=29), and surgery with chemoradiotherapy (CRT, n=49). Results The median follow-up period was 63 months. The 5-year rates of locoregional failure-free survival (LRFFS), distant metastasis-free survival (DMFS), progression-free survival (PFS), and overall survival (OS) for all patients were 56.5%, 59.7%, 36.6%, and 42.0%, respectively. In multivariate analysis, surgery with RT and CRT was a significant prognostic factor for LRFFS, and surgery with CTx was a significant prognostic factor for DMFS, and surgery with CTx, RT, and CRT was a significant prognostic factor for PFS (p < 0.05). Surgery with CTx and CRT showed association with superior OS (p < 0.05), and surgery with RT had marginal significance (p=0.078). In multivariate analysis of the R1 resection patients, surgery with CRT showed significant association with OS (p < 0.05). Conclusion Adjuvant RT and CTx may be helpful in improving clinical outcomes of patients with resected EHBDC who have a high risk of disease recurrence, particularly R1 resection patients. Conduct of additional prospective, larger-scale studies will be required in order to confirm the benefit of adjuvant RT and CTx in these patients. © 2016 by the Korean Cancer Association. | - |
dc.language | English | - |
dc.publisher | Korean Cancer Association | - |
dc.subject | Adjuvant radiotherapy | - |
dc.subject | Biliary tract neoplasms | - |
dc.subject | Cholangiocarcinoma | - |
dc.subject | Drug therapy | - |
dc.subject | Extrahepatic bile duct cancer | - |
dc.subject | Survival | - |
dc.title | Surgery alone versus surgery followed by chemotherapy and radiotherapy in resected extrahepatic bile duct cancer: Treatment outcome analysis of 336 patients | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 48 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 583 | - |
dc.relation.lastpage | 595 | - |
dc.relation.journaltitle | Cancer Research and Treatment | - |
dc.identifier.doi | 10.4143/crt.2015.091 | - |
dc.identifier.wosid | WOS:000374197200019 | - |
dc.identifier.scopusid | 2-s2.0-84963828943 | - |
dc.author.google | Im J.H. | - |
dc.author.google | Seong J. | - |
dc.author.google | Lee I.J. | - |
dc.author.google | Park J.S. | - |
dc.author.google | Yoon D.S. | - |
dc.author.google | Kim K.S. | - |
dc.author.google | Lee W.J. | - |
dc.author.google | Park K.R. | - |
dc.contributor.scopusid | 박경란(14040340300;57203047823;57207108839;57308917900) | - |
dc.date.modifydate | 20230118120244 | - |