Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김명래 | * |
dc.contributor.author | 김선종 | * |
dc.contributor.author | 김진우 | * |
dc.date.accessioned | 2016-08-29T12:08:42Z | - |
dc.date.available | 2016-08-29T12:08:42Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 1523-0899 | * |
dc.identifier.other | OAK-18473 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/231490 | - |
dc.description.abstract | Purpose: The aim of this study was to investigate a possible biomarker for bisphosphonate-related osteonecrosis of the jaw (BRONJ) in an animal model. Materials and Methods: Forty-eight Sprague-Dawley rats were randomly divided into the bisphosphonate group (n=36), who were injected once a week with zoledronic acid, and the control group (n=12), who were injected once a week with saline. After 6 weeks, surgical intervention was performed, and injections were continued up to 8 weeks. Rats in the bisphosphonate group were then further classified to the ONJ group, and the non-ONJ group, and biomarkers, including CTx, Glu-OC, TRACP 5b, RANKL, and OPG, were assessed at baseline (T0), at surgical intervention (T1), and at sacrifice (T2). Histomorphometric analysis for quantification of osteoclasts was performed. Results: Repeated measures analysis of variance revealed that TRACP 5b levels and the RANKL/OPG ratio were significantly decreased over time in the ONJ group compared with the non-ONJ group (p<.05). At T2, the area under the curve was 0.807 for TRACP 5b (sensitivity: 88.9%, specificity 66.7% at cutoff) and 0.765 for the RANKL/OPG ratio (sensitivity: 77.8%, specificity 62.9% at cutoff). TRACP 5b showed a lower least significant change (29.6%) with lower intra-assay coefficient of variability (CV; 6.32%) and interassay CV (11.20%) compared with those of the RANKL/OPG ratio (39.27%) and showed a higher signal-to-noise ratio (2.76) than that of the RANKL/OPG ratio (1.62). N.Oc/T.Ar and N.Oc/B.Ar demonstrated significantly decreased number of osteoclasts in ONJ group versus non-ONJ group. Conclusions: These results show that serum TRACP 5b and the RANKL/OPG ratio were possible biomarkers for BRONJ. These data may provide useful additional information for future ONJ research. Further studies are needed to validate these results in humans with ONJ. © 2016 Wiley Periodicals, Inc. | * |
dc.language | English | * |
dc.publisher | Blackwell Publishing Ltd | * |
dc.subject | Biomarker | * |
dc.subject | Bisphosphonate | * |
dc.subject | Osteonecrosis of the jaw | * |
dc.subject | Receptor activator of nuclear factor-κβ ligand | * |
dc.subject | Tartrate-resistant acid phosphatase | * |
dc.title | Biomarkers for Bisphosphonate-Related Osteonecrosis of the Jaw | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 18 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 281 | * |
dc.relation.lastpage | 291 | * |
dc.relation.journaltitle | Clinical Implant Dentistry and Related Research | * |
dc.identifier.doi | 10.1111/cid.12297 | * |
dc.identifier.wosid | WOS:000374043900008 | * |
dc.identifier.scopusid | 2-s2.0-84962861489 | * |
dc.author.google | Kim J.-W. | * |
dc.author.google | Cha I.-H. | * |
dc.author.google | Kim S.-J. | * |
dc.author.google | Kim M.-R. | * |
dc.contributor.scopusid | 김명래(55820385500) | * |
dc.contributor.scopusid | 김선종(55864004900) | * |
dc.contributor.scopusid | 김진우(55333003000) | * |
dc.date.modifydate | 20240130112828 | * |