View : 107 Download: 0

Synergistic combination of near-infrared irradiation and targeted gold nanoheaters for enhanced photothermal neural stimulation

Title
Synergistic combination of near-infrared irradiation and targeted gold nanoheaters for enhanced photothermal neural stimulation
Authors
Eom K.Im C.Hwang S.Eom S.Kim T.-S.Jeong H.S.Kim K.H.Byun K.M.Jun S.B.Kim S.J.
Ewha Authors
전상범
SCOPUS Author ID
전상범scopus
Issue Date
2016
Journal Title
Biomedical Optics Express
ISSN
2156-7085JCR Link
Citation
vol. 7, no. 4, pp. 1614 - 1625
Publisher
OSA - The Optical Society
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Despite a potential of infrared neural stimulation (INS) for modulating neural activities, INS suffers from limited light confinement and bulk tissue heating. Here, a novel methodology for an advanced optical stimulation is proposed by combining near-infrared (NIR) stimulation with gold nanorods (GNRs) targeted to neuronal cell membrane. We confirmed experimentally that in vitro and in vivo neural activation is associated with a local heat generation based on NIR stimulation and GNRs. Compared with the case of NIR stimulation without an aid of GNRs, combination with celltargeted GNRs allows photothermal stimulation with faster neural response, lower delivered energy, higher stimulation efficiency and stronger behavior change. Since the suggested method can reduce a requisite radiant exposure level and alleviate a concern of tissue damage, it is expected to open up new possibilities for applications to optical neuromodulations for diverse excitable tissues and treatments of neurological disorders. © 2016 Optical Society of America.
DOI
10.1364/BOE.7.001614
Appears in Collections:
엘텍공과대학 > 전자공학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE