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Trends in the distribution and antimicrobial susceptibility of causative pathogens of device-associated infection in Korean intensive care units from 2006 to 2013: Results from the Korean Nosocomial Infections Surveillance System (KONIS)

Title
Trends in the distribution and antimicrobial susceptibility of causative pathogens of device-associated infection in Korean intensive care units from 2006 to 2013: Results from the Korean Nosocomial Infections Surveillance System (KONIS)
Authors
Choi J.Y.Kwak Y.G.Yoo H.Lee S.-O.Kim H.B.Han S.H.Choi H.J.Kim H.Y.Kim S.R.Kim T.H.Lee H.Chun H.K.Kim J.-S.Eun B.W.Kim D.W.Koo H.-S.Cho E.-H.Lee K.
Ewha Authors
최희정
SCOPUS Author ID
최희정scopus
Issue Date
2016
Journal Title
Journal of Hospital Infection
ISSN
0195-6701JCR Link
Keywords
Device-associated infectionsHealthcare-associated infectionPathogenResistanceSurveillance
Publisher
W.B. Saunders Ltd
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background: For all countries, information on pathogens causing healthcare-associated infections is important in order to develop proper strategies for preventing and treating nosocomial infections. Aim: To assess the change in frequencies and antimicrobial resistance of pathogens causing device-associated infections (DAIs) in intensive care units (ICUs) in South Korea between July 2006 and June 2014. Methods: Data from the Korean Nosocomial Infections Surveillance System (KONIS) were analysed, including three major DAI types in ICUs. Findings: The frequency of Gram-negative bacteria gradually increased for central line-associated bloodstream infection (CLABSI) and ventilator-associated pneumonia (VAP) (from 24.6% to 32.6% and from 52.8% to 73.5%, respectively). By contrast, the frequency of Gram-positive bacteria decreased from 58.6% to 49.2% for CLABSI, and from 44.3% to 23.8% for VAP (P < 0.001). Staphylococcus aureus was the most frequent causative pathogen in CLABSI throughout the surveillance period, but for VAP was replaced as the most frequent pathogen by Acinetobacter baumannii as of 2010. Candida albicans was the most frequent pathogen for catheter-associated urinary tract infection. The meticillin resistance rate in S. aureus decreased from 95% to 90.2% (P < 0.001); amikacin resistance in Klebsiella pneumoniae and Escherichia coli decreased from 43.8% to 14.7% and from 15.0% to 1.8%, respectively (P < 0.001); imipenem resistance in A. baumannii increased from 52.9% to 89.8% (P < 0.001). Conclusion: The proportion of Gram-negative bacteria as nosocomial pathogens for CLABSI and VAP has increased. The prevalence of A. baumannii causing DAIs in Korean ICUs has increased rapidly, as has the rate of carbapenem resistance in these bacteria. © 2016 The Healthcare Infection Society.
DOI
10.1016/j.jhin.2015.12.012
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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