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Ceramide synthases: reexamining longevity.

Title
Ceramide synthases: reexamining longevity.
Authors
Park J.W.Pewzner-Jung Y.
Ewha Authors
박주원
SCOPUS Author ID
박주원scopus
Issue Date
2013
Journal Title
Handbook of experimental pharmacology
ISSN
0171-2004JCR Link
Citation
no. 215, pp. 89 - 107
Indexed
SCOPUS scopus
Abstract
The ceramide synthase (CerS) enzymes catalyze the formation of (dihydro) ceramide, and thereby provide critical complexity to all sphingolipids (SLs) with respect to their acyl chain length. This review summarizes the progress in the field of CerS from the time of their discovery more than a decade ago as Longevity assurance (Lass) genes in yeast, until the recent development of CerS-deficient mouse models. Human hereditary CerS disorders are yet to be discovered. However, the recent findings in CerS mutant animals highlight the important physiological role of these enzymes. The fundamental findings with respect to CerS structure, function, localization, and regulation are discussed, as well as CerS roles in maintaining longevity in vivo.
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의과대학 > 의학과 > Journal papers
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