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[Clinicopathological characteristics of gastric cancer and survival improvement by surgical treatment in the elderly].

Title
[Clinicopathological characteristics of gastric cancer and survival improvement by surgical treatment in the elderly].
Authors
Choi J.Y.Shim K.N.Roh S.H.Tae C.H.Kim S.E.Jung H.K.Kim T.H.Jung S.A.Yoo K.Moon I.W.
Ewha Authors
문일환유권정성애정혜경심기남김태헌김성은태정현
SCOPUS Author ID
문일환scopus; 유권scopus; 정성애scopus; 정혜경scopus; 심기남scopus; 김태헌scopus; 김성은scopus; 태정현scopusscopus
Issue Date
2011
Journal Title
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
ISSN
1598-9992JCR Link
Citation
vol. 58, no. 1, pp. 9 - 19
Indexed
SCOPUS; KCI scopus
Abstract
It has been known that elderly patients with gastric cancer show worse general condition and higher comorbidities. Therefore, few elderly patients undergo surgery. This study was designed to determine clinicopathological characteristics of gastric cancer in elderly patients and evaluate their survival improvements by the surgical treatment. Gastric cancer patients, diagnosed at Ewha Womans University Mokdong Hospital between 2000 to 2004, were divided into two groups those aged ≥65 years vs. <65 years. Clinicopathological characteristics, incidence of postoperative complications, and survival time of patients in each group were analyzed. Total 370 patients were subjected and divided into the elderly and the younger group (55.4% vs. 44.6%). The elderly group showed higher incidences of hypertension and cardiovascular disease. Well differentiated adenocarcinoma was more frequently found in the elderly group (19.0% vs. 10.0%, p=0.025). There were no differences of operation time (242.6±70.7 vs. 257.3±83.8 min, p=0.115), postoperative hospital stays (15.8±10.6 vs. 14.7±9.8 days, p=0.361), and incidence of any complications (6.7% vs. 9.9%, p=0.309) between the two subgroups. The significant factors related with the elderly patient's survival were the tumor-node-metastasis (TNM) stage (stage I, hazard ratio [HR] 1.00; stage II, HR 1.28, 95% confidence interval [CI] 0.44-3.72; stage III, HR 4.06, 95% CI 2.08-7.92, stage IV, HR 9.78, 95% CI 4.97-19.26; p<0.001) and the treatment modality (laparoscopy, HR 1.00; open surgery, HR 3.90, 95% CI 2.43-6.26; p<0.001). The elderly patients who underwent gastric cancer surgery showed prolonged survival on TNM stage I, II, and III than those who were treated conservatively. In the elderly patients with gastric cancer, those who had received surgical treatments showed significantly higher survival rate than those who had treated conservatively. Therefore, aggressive surgical treatments should be seriously considered even for the elderly patients with gastric cancer.
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의학전문대학원 > 의학과 > Journal papers
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