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Phylogenetic analysis of human bocavirus in hospitalized children with acute respiratory tract infection in Korea

Title
Phylogenetic analysis of human bocavirus in hospitalized children with acute respiratory tract infection in Korea
Authors
Ahn J.G.Choi S.Y.Kim D.S.Kim K.H.
Ewha Authors
안종균
SCOPUS Author ID
안종균scopus
Issue Date
2012
Journal Title
Korean Journal of Pediatric Infectious Diseases
ISSN
1226-3923JCR Link
Citation
vol. 19, no. 2, pp. 71 - 78
Indexed
SCOPUS; KCI scopus
Abstract
Purpose: Human bocavirus (hBoV), a recently discovered virus, has been detected in children with respiratory tract infections worldwide. The aim of this study was to analyze the frequency and molecular phylogeny of hBoV in the respiratory samples of children with acute respiratory tract infections in 2010. Methods: Nasopharyngeal samples were collected from 953 children with lower respiratory tract infections at Severance children's hospital in Korea from January 2010 to December 2010. We applied the multiplex PCR technique for the identification of 12 respiratory viruses from the samples. Among the total specimens, hBoV positive samples were subjected to phylogenetic analysis by sequencing a fragment of the VP1/VP2 gene junction. Results: hBoV was detected in 141 (14.8%) among 953 patients. The 61.7% of hBoV-positive samples were found to co-exist with other respiratory viruses. The results of phylogenetic analysis showed that all 141 hBoV-positive isolates were identified as hBoV 1, revealing a high similarity among the isolates (>98%). Conclusion: hBoV 1 with minimal sequence variations circulated in children with acute respiratory infections during 2010. More research is needed to determine the clinical severity and outcomes of the minimal sequence variations.
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의료원 > 의료원 > Journal papers
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