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Remote-Controlled Release of Singlet Oxygen by the Plasmonic Heating of Endoperoxide-Modified Gold Nanorods: Towards a Paradigm Change in Photodynamic Therapy

Title
Remote-Controlled Release of Singlet Oxygen by the Plasmonic Heating of Endoperoxide-Modified Gold Nanorods: Towards a Paradigm Change in Photodynamic Therapy
Authors
Kolemen S.Ozdemir T.Lee D.Kim G.M.Karatas T.Yoon J.Akkaya E.U.
Ewha Authors
윤주영
SCOPUS Author ID
윤주영scopus
Issue Date
2016
Journal Title
Angewandte Chemie - International Edition
ISSN
1433-7851JCR Link
Citation
vol. 55, no. 11, pp. 3606 - 3610
Keywords
endoperoxidesnanorodsphotodynamic therapyphotosensitizerssinglet oxygen
Publisher
Wiley-VCH Verlag
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The photodynamic therapy of cancer is contingent upon the sustained generation of singlet oxygen in the tumor region. However, tumors of the most metastatic cancer types develop a region of severe hypoxia, which puts them beyond the reach of most therapeutic protocols. More troublesome, photodynamic action generates acute hypoxia as the process itself diminishes cellular oxygen reserves, which makes it a self-limiting method. Herein, we describe a new concept that could eventually lead to a change in the 100 year old paradigm of photodynamic therapy and potentially offer solutions to some of the lingering problems. When gold nanorods with tethered endoperoxides are irradiated at 808 nm, the endoperoxides undergo thermal cycloreversion, resulting in the generation of singlet oxygen. We demonstrate that the amount of singlet oxygen produced in this way is sufficient for triggering apoptosis in cell cultures. EPT sees the light: When gold nanorods with tethered endoperoxides are irradiated with near-infrared light, the endoperoxides undergo thermal cycloreversion, resulting in the generation of singlet oxygen. The amount of singlet oxygen generated by these nanocomposites is sufficient for triggering apoptosis in cell cultures. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
DOI
10.1002/anie.201510064
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자연과학대학 > 화학·나노과학전공 > Journal papers
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