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An integrative approach to precision cancer medicine using patient-derived xenografts

Title
An integrative approach to precision cancer medicine using patient-derived xenografts
Authors
Cho S.-Y.Kang W.Han J.Y.Min S.Kang J.Lee A.Kwon J.Y.Lee C.Park H.
Ewha Authors
Charles Lee박한수조성엽
SCOPUS Author ID
Charles Leescopus; 박한수scopus; 조성엽scopus
Issue Date
2016
Journal Title
Molecules and Cells
ISSN
1016-8478JCR Link
Citation
vol. 39, no. 2, pp. 77 - 86
Keywords
Cancer drug developmentCancer genomicsPatient-derived xenograftsPrecision medicine
Publisher
Korean Society for Molecular and Cellular Biology
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Cancer is a heterogeneous disease caused by diverse genomic alterations in oncogenes and tumor suppressor genes. Despite recent advances in high-throughput sequencing technologies and development of targeted therapies, novel cancer drug development is limited due to the high attrition rate from clinical studies. Patient-derived xenografts (PDX), which are established by the transfer of patient tumors into immunodeficient mice, serve as a platform for co-clinical trials by enabling the integration of clinical data, genomic profiles, and drug responsiveness data to determine precisely targeted therapies. PDX models retain many of the key characteristics of patients’ tumors including histology, genomic signature, cellular heterogeneity, and drug responsiveness. These models can also be applied to the development of biomarkers for drug responsiveness and personalized drug selection. This review summarizes our current knowledge of this field, including methodologic aspects, applications in drug development, challenges and limitations, and utilization for precision cancer medicine. © The Korean Society for Molecular and Cellular Biology. All rights reserved.
DOI
10.14348/molcells.2016.2350
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일반대학원 > 생명과학과 > Journal papers
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