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Comparison between the effectiveness of oral phloroglucin and cimetropium bromide as premedication for diagnostic esophagogastroduodenoscopy: An open-label, randomized, comparative study

Title
Comparison between the effectiveness of oral phloroglucin and cimetropium bromide as premedication for diagnostic esophagogastroduodenoscopy: An open-label, randomized, comparative study
Authors
Yun H.-W.Shim K.-N.Na S.-K.Ryu J.-I.Lee M.-J.Song E.-M.Kim S.-E.Jung H.-K.Jung S.-A.
Ewha Authors
정성애정혜경심기남김성은
SCOPUS Author ID
정성애scopus; 정혜경scopus; 심기남scopus; 김성은scopus
Issue Date
2015
Journal Title
Clinical Endoscopy
ISSN
2234-2400JCR Link
Citation
vol. 48, no. 1, pp. 48 - 51
Keywords
CimetropiumPhloroglucinUpper endoscopy
Publisher
Korean Society of Gastrointestinal Endoscopy
Indexed
SCOPUS; KCI scopus
Abstract
Background/Aims: Suppression of gastrointestinal (GI) peristalsis during GI endoscopy commonly requires antispasmodic agents such as hyoscine butylbromide, atropine, glucagon, and cimetropium bromide. This study examined the efficacy of oral phloroglucin for the suppression of peristalsis, its impact on patient compliance, and any associated complications, and compared it with intravenous or intramuscular cimetropium bromide administration. Methods: This was a randomized, investigator-blind, prospective comparative study. A total of 172 patients were randomized into two groups according to the following medications administered prior to upper endoscopy: oral phloroglucin (group A, n=86), and cimetropium bromide (group B, n=86). The numbers and the degrees of peristalsis events at the antrum and second duodenal portion were assessed for 30 seconds. Results: A significantly higher number of gastric peristalsis events was observed in group A (0.49 vs. 0.08, p<0.001), but the difference was not clinically significant. No significant difference between both groups was found in the occurrence of duodenal peristalsis events (1.79 vs. 1.63, p=0.569). The incidence of dry mouth was significantly higher with cimetropium bromide than with phloroglucin (50% vs. 15.1%, p<0.001). Conclusions: Oral phloroglucin can be used as an antispasmodic agent during upper endoscopy, and shows antispasmodic efficacy and adverse effects similar to those of cimetropium bromide. © 2015 Korean Society of Gastrointestinal Endoscopy.
DOI
10.5946/ce.2015.48.1.48
Appears in Collections:
의과대학 > 의학과 > Journal papers
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