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Dual delivery of biological therapeutics for multimodal and synergistic cancer therapies

Title
Dual delivery of biological therapeutics for multimodal and synergistic cancer therapies
Authors
Jang B.Kwon H.Katila P.Lee S.J.Lee H.
Ewha Authors
이승진이혁진
SCOPUS Author ID
이승진scopus; 이혁진scopus
Issue Date
2016
Journal Title
Advanced Drug Delivery Reviews
ISSN
0169-409XJCR Link
Citation
vol. 98, pp. 113 - 133
Keywords
Biological therapeuticsCancer therapyDual delivery
Publisher
Elsevier
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Cancer causes > 8.2 million deaths annually worldwide; thus, various cancer treatments have been investigated over the past decades. Among them, combination drug therapy has become extremely popular, and treatment with more than one drug is often necessary to achieve appropriate anticancer efficacy. With the development of nanoformulations and nanoparticulate-based drug delivery, researchers have explored the feasibility of dual delivery of biological therapeutics to overcome the current drawbacks of cancer therapy. Compared with the conventional single drug therapy, dual delivery of therapeutics has provided various synergistic effects in addition to offering multimodality to cancer treatment. In this review, we highlight and summarize three aspects of dual-delivery systems for cancer therapy. These include (1) overcoming drug resistance by the dual delivery of chemical drugs with biological therapeutics for synergistic therapy, (2) targeted and controlled drug release by the dual delivery of drugs with stimuli-responsive nanomaterials, and (3) multimodal theranostics by the dual delivery of drugs and molecular imaging probes. Furthermore, recent developments, perspectives, and new challenges regarding dual-delivery systems for cancer therapy are discussed. © 2015 Elsevier B.V..
DOI
10.1016/j.addr.2015.10.023
Appears in Collections:
약학대학 > 약학과 > Journal papers
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