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Mast Cells Contribute to Radiation-Induced Vascular Hyperpermeability

Title
Mast Cells Contribute to Radiation-Induced Vascular Hyperpermeability
Authors
Park K.R.Monsky W.L.Lee C.G.Song C.H.Kim D.H.Jain R.K.Fukumura D.
Ewha Authors
박경란
SCOPUS Author ID
박경란scopus
Issue Date
2016
Journal Title
Radiation Research
ISSN
0033-7587JCR Link
Citation
vol. 185, no. 2, pp. 182 - 189
Publisher
Radiation Research Society
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Induction of vascular hyperpermeability is one of the early vascular responses to radiation exposure and is considered to contribute to subsequent fibrosis and tissue injuries. However, the mechanism underlying radiation-induced hyperpermeability has not yet been clearly elucidated. Here, we provide experimental evidence indicating that mast cells contribute to the increase in vascular permeability for albumin in normal mouse skin after irradiation. Vascular permeability in the skin of C3H mice increased after 2, 15 and 50 Gy irradiation, peaked at 24 h after irradiation and gradually decreased thereafter to the baseline level within 3-10 days. Both the extent and duration of hyperpermeability were dose dependent. We found significant degranulation of mast cells in the skin after 15 Gy irradiation. To further investigate the role of mast cells in the radiation-induced increase in vascular permeability, we measured vascular permeability in the skin of mast cell-deficient mice (WWv) and their wild-type littermates at 24 h after irradiation. Vascular permeability in WWv mice did not change, whereas that in wild-type mice significantly increased after irradiation. There were no appreciable changes in the total tissue levels of vascular endothelial growth factor or endothelial nitric oxide synthase after 15 Gy irradiation and there was no detectable expression of inducible nitric oxide synthase. Collectively, these results show that exposure to radiation induces vascular hyperpermeability in a dose-dependent manner and that mast cells contribute to this process. © 2015 by Radiation Research Society.
DOI
10.1667/RR14190.1
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의료원 > 의료원 > Journal papers
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