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FK506 regulates pigmentation by maturing the melanosome and facilitating their transfer to keratinocytes

Title
FK506 regulates pigmentation by maturing the melanosome and facilitating their transfer to keratinocytes
Authors
Jung H.Chung H.Chang S.E.Kang D.-H.Oh E.-S.
Ewha Authors
강덕희오억수
SCOPUS Author ID
강덕희scopus; 오억수scopus
Issue Date
2016
Journal Title
Pigment Cell and Melanoma Research
ISSN
1755-1471JCR Link
Citation
vol. 29, no. 2, pp. 199 - 209
Keywords
FK506Melano-someMelanogenesisTyrosinaseVitiligo
Publisher
Blackwell Publishing Ltd
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Despite the clinical ability of topical tacrolimus (FK506) to effectively promote repigmentation in vitiligo, the underlying mechanism through which FK506 regulates melanogenesis was previously unclear. We found that FK506 treatment increased the melanin contents (especially that of eumelanin) in both melanocytes and melanoma cells. This treatment did not affect the transcription levels of tyrosinase, suggesting that FK506 increases melanin synthesis by regulating cellular levels of tyrosinase. Interestingly, FK506 promoted melanosome maturation by increasing melanosomal pH (a marker of melanosome maturation), thereby enhancing the stability of melanosome-localized tyrosinase. In addition, FK506 enhanced UVB-mediated melanosome secretion, the uptake of melanosomes by HaCaT cells, and the transfer of melanosomes to keratinocytes co-cultured with melanocytes. Together, these findings suggest that FK506 contributes to melanin synthesis by regulating the maturation of melanosomes and their transfer to keratinocytes. This offers a novel regulatory mechanism through which FK506 and UVB can have a combined effect on melanogenesis. © 2016 John Wiley & Sons A/S.
DOI
10.1111/pcmr.12443
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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