Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 홍근 | * |
dc.date.accessioned | 2016-08-29T12:08:02Z | - |
dc.date.available | 2016-08-29T12:08:02Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 0168-8278 | * |
dc.identifier.other | OAK-16486 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/231086 | - |
dc.description.abstract | Background & Aims: Given the organ shortage for liver transplantation (LT) and the limitations of the current morphology-based selection criteria, improved criteria are needed to achieve the maximum benefit of LT for hepatocellular carcinoma (HCC). We hypothesized that a combination of biological markers may better predict the prognosis than the Milan criteria. Methods: HCC patients (n=123) with preoperative data on serum alpha-fetoprotein (AFP) levels and 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) positivity underwent live-donor LT between January 2003 and December 2009. The cut-off values for serum AFP levels (200ng/ml) and 18F-FDG PET positivity (1.10) for tumor recurrence were determined by c-statistics using receiver operating characteristic curves. Univariate and multivariate analyses with preoperative variables were performed to find pre-transplant prognostic factors. Disease-free survival rates and overall survival rates were analysed with regard to serum AFP levels and 18F-FDG PET positivity. Results: The 5-year disease-free survival rates and overall survival rates were 80.3% and 81.6% respectively. 18F-FDG PET positivity (hazard ratio (HR) 9.766, 95% CI 3.557-26.816; p <0.001) and serum AFP level (HR 6.234, 95% CI 2.643-14.707; p <0.001) were the only significant pre-transplant prognostic factors in the multivariate analysis; tumor number and size were not significant.A combination of criteria showed that the biologically high-risk group (AFP level ≥200. ng/ml and PET-positive) had an HR of 29.069 (95% CI 8.797-96.053; p <0.001) compared with the double-negative group. Use of the Milan criteria yielded an HR of 1.351 (95% CI 0.500-3.652; p = 0.553). Conclusions: The combination of the serum AFP level and 18F-FDG PET data predicted better outcomes than those using the Milan criteria, improving objectivity when adult-to-adult living donor LT is contemplated. © 2015 European Association for the Study of the Liver. | * |
dc.language | English | * |
dc.publisher | Elsevier | * |
dc.subject | Alpha-fetoproteins | * |
dc.subject | Biological factors | * |
dc.subject | Fluorodeoxyglucose F18 | * |
dc.subject | Hepatocellular carcinoma | * |
dc.subject | Liver transplantation | * |
dc.subject | Living donors | * |
dc.subject | Positron emission tomography | * |
dc.title | Preoperative alpha-fetoprotein and 18F-FDG PET predict tumor recurrence better than Milan criteria in living donor liver transplantation | * |
dc.type | Article in Press | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Journal of Hepatology | * |
dc.identifier.doi | 10.1016/j.jhep.2015.11.033 | * |
dc.identifier.scopusid | 2-s2.0-84958191688 | * |
dc.author.google | Hong G. | * |
dc.author.google | Suh K.-S. | * |
dc.author.google | Suh S.-W. | * |
dc.author.google | Yoo T. | * |
dc.author.google | Kim H. | * |
dc.author.google | Park M.-S. | * |
dc.author.google | Choi Y.R. | * |
dc.author.google | Paeng J.C. | * |
dc.author.google | Yi N.-J. | * |
dc.author.google | Lee K.-W. | * |
dc.contributor.scopusid | 홍근(55558687200) | * |
dc.date.modifydate | 20231123115615 | * |