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Nanocomposite versus Mesocomposite for Osteogenic Differentiation of Tonsil-Derived Mesenchymal Stem Cells

Title
Nanocomposite versus Mesocomposite for Osteogenic Differentiation of Tonsil-Derived Mesenchymal Stem Cells
Authors
Moon H.J.Patel M.Chung H.Jeong B.
Ewha Authors
정병문
SCOPUS Author ID
정병문scopus
Issue Date
2016
Journal Title
Advanced Healthcare Materials
ISSN
2192-2640JCR Link
Citation
vol. 5, no. 3, pp. 353 - 363
Keywords
Calcium phosphateMesocrystalsOsteogenic differentiationPolypeptide thermogelsTonsil-derived mesenchymal stem cells, stem cells
Publisher
Wiley-VCH Verlag
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Injectable inorganic/organic composite systems consisting of well-defined mesocrystals (4-8 μm) of calcium phosphate and polypeptide thermogel significantly enhance the osteogenic differentiation of the tonsil derived mesenchymal stem cells (TMSCs). Compared to composite systems incorporating nanoparticles (10-100 nm) or pure hydrogel systems, osteogenic biomarkers including alkaline phosphatase (ALP), bone morphogenetic protein 2, and osteocalcin are highly expressed at both the mRNA level and the protein level in the mesocrystal composite systems. ALP activity of differentiated cells is also significantly higher in the mesocomposite systems compared to the nanocomposite systems or the pure hydrogel systems. The mesocomposite systems provide not only hard surfaces for binding the cells/proteins by the inorganic mesocrystals but also a soft matrix for holding the cells by the hydrogel. Through the current research, (1) a novel method of preparing mesocrystals is developed, (2) TMSCs are proved as a new resource of stem cells, and (3) the mesocomposite systems are proved to be a promising tool in controlling stem cell differentiation. (4) Finally, the research emphasizes the significance of mesoscience as a new perspective of science in controlling cell and material interfaces. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
DOI
10.1002/adhm.201500558
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자연과학대학 > 화학·나노과학전공 > Journal papers
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