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Combined effect of folate and adiposity on homocysteine in children at three years of age

Title
Combined effect of folate and adiposity on homocysteine in children at three years of age
Authors
Cho S.J.Lee H.A.Park B.H.Ha E.H.Kim Y.J.Park E.A.Park H.
Ewha Authors
하은희박은애김영주박혜숙조수진박보현이혜아
SCOPUS Author ID
하은희scopus; 박은애scopus; 김영주scopus; 박혜숙scopus; 조수진scopus; 박보현scopus; 이혜아scopus
Issue Date
2016
Journal Title
Nutrition Research and Practice
ISSN
1976-1457JCR Link
Citation
vol. 10, no. 1, pp. 74 - 80
Keywords
AdiposityCardiovascular riskChildrenFolateHomocysteine
Publisher
Korean Nutrition Society
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
BACKGROUND/OBJECTIVES: Cardiovascular diseases is a major cause of death and is responsible for 23.8% of deaths in Korea. Clinical symptoms manifest in adulthood, but susceptibility begins in utero. Elevated homocysteine levels and adiposity might be linked to a greater risk in children as well as adults. We hypothesized that those who have simultaneous risk for folate and adiposity would be affected with elevated homocysteine levels at 3 years of age. SUBJECTS/METHODS: From the ongoing birth cohort at Ewha Womans University Mok-Dong Hospital, we compared adiposity parameters, serum homocysteine, and folate levels in 238 children (118 boys and 120 girls) at three years of age. The relationship between birth outcome, current weight and body mass index (BMI), postnatal growth, and homocysteine level were assessed using correlation and general linear model. Additionally, we assessed the combined effect between blood folate status and adiposity on current homocysteine levels. RESULTS: Birth characteristics were not correlated with homocysteine. Current weight, BMI, upper-arm circumference, skinfold thickness, waist circumference, and hip circumference were positively correlated with homocysteine at three years of age (P < 0.05). Folate level was negatively correlated with homocysteine at three years of age (P < 0.0001). A relative high anthropometric measure which is compatible with adiposity and low folate level was associated with high homocysteine levels. CONCLUSION: We found a combined effect of adiposity and folate levels with homocysteine levels at three years of age. This implicates the beneficial role of folate supplementation in the high-risk population at an early age. © 2016 The Korean Nutrition Society and the Korean Society of Community Nutrition.
DOI
10.4162/nrp.2016.10.1.74
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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