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Blood pressure variability and the development of early neurological deterioration following acute ischemic stroke

Title
Blood pressure variability and the development of early neurological deterioration following acute ischemic stroke
Authors
Chung J.-W.Kim N.Kang J.Park S.H.Kim W.-J.Ko Y.Park J.H.Lee J.S.Lee J.Yang M.H.Jang M.S.Oh C.W.Kwon O.-K.Jung C.Kim B.J.Han M.-K.Gorelick P.B.Bae H.-J.
Ewha Authors
박정현
Issue Date
2015
Journal Title
Journal of Hypertension
ISSN
0263-6352JCR Link
Citation
vol. 33, no. 10, pp. 2099 - 2106
Keywords
blood pressurecerebral infarctionprognosisrisk factors
Publisher
Lippincott Williams and Wilkins
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objectives: Early neurological deterioration (END) is a common condition associated with poor outcome after acute ischemic stroke. We studied association between blood pressure (BP) variability and development of END. Methods: In this retrospective observational study, we studied a consecutive series of patients hospitalized for acute ischemic stroke within 24h of onset. The primary outcome of interest was the development of END according to predefined criteria within the first 72h of stroke onset. During this period, the mean, maximum (max), and minimum (min) values for the SBP and DBP were measured. The following parameters of BP variability were calculated for the SBP and DBP: the difference between the maximum and minimum (max-min), the SD, and the coefficient of variation. Results: Of the 1161 patients enrolled in the study (mean age, 67.5±13.3 years; 59.6% men), 210 (18.1%) developed END. All of the BP variability parameters were linearly associated with END independent of mean BP and potential clinical variables (P values<0.05 on likelihood ratio tests for trend), except for SBPmax-min. Among the other BP parameters, SBPmean, SBPmax, DBPmax, and DBPmin were independently associated with END. After adjustments for potential confounders, the odds for END increased 14-21% with each increase of one standard deviation in the BP variability parameter. Conclusion: BP variability is independently and linearly associated with the development of neurologic deterioration in acute stage of ischemic stroke. © 2015 Wolters Kluwer Health, Inc.
DOI
10.1097/HJH.0000000000000675
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연구기관 > 의과학연구소 > Journal papers
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