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Effects of Creatine Monohydrate Augmentation on Brain Metabolic and Network Outcome Measures in Women With Major Depressive Disorder

Title
Effects of Creatine Monohydrate Augmentation on Brain Metabolic and Network Outcome Measures in Women With Major Depressive Disorder
Authors
Yoon, SujungKim, Jieun E.Hwang, JaeukKim, Tae-SukKang, Hee JinNamgung, EunBan, SoonhyunOh, SubinYang, JeongwonRenshaw, Perry F.Lyoo, In Kyoon
Ewha Authors
김지은류인균윤수정
SCOPUS Author ID
김지은scopus; 류인균scopus; 윤수정scopus
Issue Date
2016
Journal Title
BIOLOGICAL PSYCHIATRY
ISSN
0006-3223JCR Link1873-2402JCR Link
Citation
vol. 80, no. 6, pp. 439 - 447
Keywords
AntidepressantBrain bioenergeticsCreatine monohydrateMajor depressive disorderNetwork organizationSelective serotonin reuptake inhibitor
Publisher
ELSEVIER SCIENCE INC
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
BACKGROUND: Creatine monohydrate (creatine) augmentation has the potential to accelerate the clinical responses to and enhance the overall efficacy of selective serotonin reuptake inhibitor treatment in women with major depressive disorder (MDD). Although it has been suggested that creatine augmentation may involve the restoration of brain energy metabolism, the mechanisms underlying its antidepressant efficacy are unknown. METHODS: In a randomized, double-blind, placebo-controlled trial, 52 women with MDD were assigned to receive either creatine augmentation or placebo augmentation of escitalopram; 34 subjects participated in multimodal neuroimaging assessments at baseline and week 8. Age-matched healthy women (n = 39) were also assessed twice at the same intervals. Metabolic and network outcomes were measured for changes in prefrontal N-acetylaspartate and changes in rich club hub connections of the structural brain network using proton magnetic resonance spectroscopy and diffusion tensor imaging, respectively. RESULTS: We found MDD-related metabolic and network dysfunction at baseline. Improvement in depressive symptoms was greater in patients receiving creatine augmentation relative to placebo augmentation. After 8 weeks of treatment, prefrontal N-acetylaspartate levels increased significantly in the creatine augmentation group compared with the placebo augmentation group. Increment in rich club hub connections was also greater in the creatine augmentation group than in the placebo augmentation group. CONCLUSIONS: N-acetylaspartate levels and rich club connections increased after creatine augmentation of selective serotonin reuptake inhibitor treatment. Effects of creatine administration on brain energy metabolism and network organization may partly underlie its efficacy in treating women with MDD.
DOI
10.1016/j.biopsych.2015.11.027
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일반대학원 > 뇌·인지과학과 > Journal papers
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