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Physiological parameters in the blood of a murine stress-induced depression model before and after repeated passive exercise

Title
Physiological parameters in the blood of a murine stress-induced depression model before and after repeated passive exercise
Authors
Kim T.-K.Park J.-Y.Han P.-L.
Ewha Authors
한평림
SCOPUS Author ID
한평림scopus
Issue Date
2015
Journal Title
Endocrinology and Metabolism
ISSN
2093-596XJCR Link
Citation
vol. 30, no. 3, pp. 371 - 380
Keywords
Blood pHExerciseExercise animal modelLactatePhysiological parameters
Publisher
Korean Endocrine Society
Indexed
SCOPUS; KCI scopus
Abstract
Background: Animal models are necessary to study the mechanism underlying the effects of exercise on depression but an effective procedure for exercise treatment and exercise effects on physiological parameters in a specific depression model need to be characterized. Methods: Physiological parameters including lactate, partial pressue of O2 (pO2) and CO2 (pCO2) saturated O2 (sO2), pH, HCO3, total CO2 (TCO2), and base excess extracellular fluid (BEecf) levels in the blood were measured after treatment with passive exercise in normal mice and a stress-induced depression model. Results: Normal mice or mice that were subjected to daily 2-hour restraint for 14 days (2 hours×14 days of restraint) were placed on a running wheel that was rotating at a speed of 9 m/min for 1 hour per day for 1 to 21 days. After repeated exercise in mice that were previously subjected to 2 hours×14 days restraint, plasma lactate levels decreased, the levels of pO2, sO2, and pH tended to increase, and the levels of pCO2 decreased in the absence of significant changes in HCO3, TCO2, and BEecf. However, none of these changes were additive to the stress effects or were much more severe than those induced after repeated passive exercise in normal mice. Conclusion: These results suggest that passive exercise for 1 hour daily for 14 to 21 consecutive days on a running wheel rotating at a speed of 9 m/min may be used as an exercise protocol without inducing severe additive effects on physiological burdens. © 2015 Korean Endocrine Society.
DOI
10.3803/EnM.2015.30.3.371
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일반대학원 > 뇌·인지과학과 > Journal papers
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