Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이윤실 | * |
dc.date.accessioned | 2016-08-29T12:08:52Z | - |
dc.date.available | 2016-08-29T12:08:52Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 1471-2156 | * |
dc.identifier.other | OAK-16314 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/230994 | - |
dc.description.abstract | Background: Despite the emergence of stereotactic body radiotherapy (SBRT) for treatment of medically inoperable early-stage non-small-cell lung cancer patients, the molecular effects of focal exposure of limited lung volumes to high-dose radiation have not been fully characterized. This study was designed to identify molecular changes induced by focal high-dose irradiation using a mouse model of SBRT. Results: Central areas of the mouse left lung were focally-irradiated (3mm in diameter) with a single high-dose of radiation (90Gy). Temporal changes in gene expression in the irradiated and non-irradiated neighboring lung regions were analyzed by microarray. For comparison, the long-term effect (12months) of 20Gy radiation on a diffuse region of lung was also measured. The majority of genes were down-regulated in the focally-irradiated lung areas at 2 to 3weeks after irradiation. This pattern of gene expression was clearly different than gene expression in the diffuse region of lungs exposed to low-dose radiation. Ontological and pathway analyses indicated these down-regulated genes were mainly associated with organ development. Although the number was small, genes that were up-regulated after focal irradiation were associated with immune-related functions. The temporal patterns of gene expression and the associated biological functions were also similar in non-irradiated neighboring lung regions, although statistical significance was greatly reduced when compared with those from focally-irradiated areas of the lung. From network analysis of temporally regulated genes, we identified inter-related modules associated with diverse functions, including organ development and the immune response, in both the focally-irradiated regions and non-irradiated neighboring lung regions. Conclusions: Focal exposure of lung tissue to high-dose radiation induced expression of genes associated with organ development and the immune response. This pattern of gene expression was also observed in non-irradiated neighboring areas of lung tissue, indicating a global lung response to focal high-dose irradiation. © 2016 Kim et al. | * |
dc.language | English | * |
dc.publisher | BioMed Central Ltd. | * |
dc.subject | Focal radiation | * |
dc.subject | Immune response | * |
dc.subject | Microarray | * |
dc.subject | Organ development | * |
dc.subject | Stereotactic body radiotherapy | * |
dc.title | Focal exposure of limited lung volumes to high-dose irradiation down-regulated organ development-related functions and up-regulated the immune response in mouse pulmonary tissues | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 17 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | BMC Genetics | * |
dc.identifier.doi | 10.1186/s12863-016-0338-9 | * |
dc.identifier.wosid | WOS:000368882300001 | * |
dc.identifier.scopusid | 2-s2.0-84956576163 | * |
dc.author.google | Kim B.-Y. | * |
dc.author.google | Jin H. | * |
dc.author.google | Lee Y.-J. | * |
dc.author.google | Kang G.-Y. | * |
dc.author.google | Cho J. | * |
dc.author.google | Lee Y.-S. | * |
dc.contributor.scopusid | 이윤실(17137192000) | * |
dc.date.modifydate | 20240130115944 | * |