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High hydrostatic pressure extract of red ginseng attenuates inflammation in rats with high-fat diet induced obesity

Title
High hydrostatic pressure extract of red ginseng attenuates inflammation in rats with high-fat diet induced obesity
Authors
Jung S.Lee M.-S.Shin Y.Kim C.-T.Kim I.-H.Kim Y.
Ewha Authors
김양하
SCOPUS Author ID
김양하scopus
Issue Date
2015
Journal Title
Preventive Nutrition and Food Science
ISSN
2287-1098JCR Link
Citation
vol. 20, no. 4, pp. 253 - 259
Keywords
Gene expressionHigh hydrostatic pressureHigh-fat dietInflammationRed ginseng
Publisher
Korean Society of Food Science and Nutrition
Indexed
SCOPUS; KCI scopus
Abstract
Chronic low-grade inflammation is associated with obesity. This study investigated effect of high hydrostatic pressure extract of red ginseng (HRG) on inflammation in rats with high-fat (HF) diet induced obesity. Male, Sprague-Dawley rats (80∼110 g) were randomly divided into two groups, and fed a 45% HF diet (HF) and a 45% HF diet containing 1.5% HRG (HF+HRG) for 14 weeks. At the end of the experiment, the serum leptin level was reduced by the HRG supplementation. The mRNA expression of genes related to adipogenesis including peroxisome proliferator-activated receptorgamma and adipocyte protein 2 was down-regulated in the white adipose tissue (WAT). The mRNA levels of major inflammatory cytokines such as tumor necrosis factor-α, monocyte chemoattractant protein 1, and interleukin-6 were remarkably down-regulated by the HRG in WAT. These results suggest that HRG might be beneficial in ameliorating the inflammation-associated health complications by suppressing adipogenic and pro-inflammatory gene expression. Copyright © 2015 by The Korean Society of Food Science and Nutrition. All rights Reserved.
DOI
10.3746/pnf.2015.20.4.253
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
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