Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 황은숙 | * |
dc.date.accessioned | 2016-08-29T12:08:49Z | - |
dc.date.available | 2016-08-29T12:08:49Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 1016-8478 | * |
dc.identifier.other | OAK-16247 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/230966 | - |
dc.description.abstract | The TAZ activator 2-butyl-5-methyl-6-(pyridine-3-yl)-3- [2'-(1H-tetrazole-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5- b]pyridine] (TM-25659) inhibits adipocyte differentiation by interacting with peroxisome proliferator-activated receptor gamma. 1 TM-25659 was previously shown to decrease weight gain in a high fat (HF) diet-induced obesity (DIO) mouse model. However, the fundamental mechanisms underlying the effects of TM-25659 remain unknown. Therefore, we investigated the effects of TM-25659 on skeletal muscle functions in C2 myotubes and C57BL/6J mice. We studied the molecular mechanisms underlying the contribution of TM-25659 to palmitate (PA)-induced insulin resistance in C2 myotubes. TM-25659 improved PAinduced insulin resistance and inflammation in C2 myotubes. In addition, TM-25659 increased FGF21 mRNA expression, protein levels, and FGF21 secretion in C2 myotubes via activation of GCN2 pathways (GCN2-phosphoeIF2α- ATF4 and FGF21). This beneficial effect of TM-25659 was diminished by FGF21 siRNA. C57BL/6J mice were fed a HF diet for 30 weeks. The HF-diet group was randomly divided into two groups for the next 14 days: the HF-diet and HF-diet + TM-25659 groups. The HF diet + TM-25659- treated mice showed improvements in their fasting blood glucose levels, insulin sensitivity, insulin-stimulated Akt phosphorylation, and inflammation, but neither body weight nor food intake was affected. The HF diet + TM- 25659-treated mice also exhibited increased expression of both FGF21 mRNA and protein. These data indicate that TM-25659 may be beneficial for treating insulin resistance by inducing FGF21 in models of PA-induced insulin resistance and HF diet-induced insulin resistance. © The Korean Society for Molecular and Cellular Biology. All rights reserved. | * |
dc.language | English | * |
dc.publisher | Korean Society for Molecular and Cellular Biology | * |
dc.subject | FGF21 | * |
dc.subject | GCN2 | * |
dc.subject | Inflammation | * |
dc.subject | Insulin resistance | * |
dc.subject | TM-25659 | * |
dc.title | TM-25659-induced activation of FGF21 level decreases insulin resistance and inflammation in skeletal muscle via GCN2 pathways | * |
dc.type | Article | * |
dc.relation.issue | 12 | * |
dc.relation.volume | 38 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 1037 | * |
dc.relation.lastpage | 1043 | * |
dc.relation.journaltitle | Molecules and Cells | * |
dc.identifier.doi | 10.14348/molcells.2015.0100 | * |
dc.identifier.wosid | WOS:000367527500003 | * |
dc.identifier.scopusid | 2-s2.0-84958063365 | * |
dc.author.google | Jung J.G. | * |
dc.author.google | Yi S.-A. | * |
dc.author.google | Choi S.-E. | * |
dc.author.google | Kang Y. | * |
dc.author.google | Kim T.H. | * |
dc.author.google | Jeon J.Y. | * |
dc.author.google | Bae M.A. | * |
dc.author.google | Ahn J.H. | * |
dc.author.google | Jeong H. | * |
dc.author.google | Hwang E.S. | * |
dc.author.google | Lee K.-W. | * |
dc.contributor.scopusid | 황은숙(8688011100) | * |
dc.date.modifydate | 20240123102458 | * |