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Insulin initiation in insulin-naïve korean type 2 diabetic patients inadequately controlled on oral antidiabetic drugs in real-world practice: The modality of insulin treatment evaluation study

Title
Insulin initiation in insulin-naïve korean type 2 diabetic patients inadequately controlled on oral antidiabetic drugs in real-world practice: The modality of insulin treatment evaluation study
Authors
Kim S.S.Kim I.J.Kim Y.K.Yoon K.H.Son H.Y.Park S.W.Sung Y.A.Baek H.S.
Ewha Authors
성연아
SCOPUS Author ID
성연아scopus
Issue Date
2015
Journal Title
Diabetes and Metabolism Journal
ISSN
2233-6079JCR Link
Citation
vol. 39, no. 6, pp. 481 - 488
Keywords
Basal insulinDiabetes mellitusKoreaPragmatic clinical trials as topicType 2
Publisher
Korean Diabetes Association
Indexed
SCOPUS; KCI scopus
Abstract
Background: The Modality of Insulin Treatment Evaluation (MOTIV) study was performed to provide real-world data concerning insulin initiation in Korean type 2 diabetes mellitus (T2DM) patients with inadequate glycemic control with oral hypoglycemic agents (OHAs). Methods: This multicenter, non-interventional, prospective, observational study enrolled T2DM patients with inadequate glycemic control (glycosylated hemoglobin [HbA1c] ≥7.0%) who had been on OHAs for ≥3 months and were already decided to introduce basal insulin by their physician prior to the start of the study. All treatment decisions were at the physician's discretion to reflect real-world practice. Results: A total of 9,196 patients were enrolled, and 8,636 patients were included in the analysis (mean duration of diabetes, 8.9 years; mean HbA1c, 9.2%). Basal insulin plus one OHA was the most frequently (51.0%) used regimen. After 6 months of basal insulin treatment, HbA1c decreased to 7.4% and 44.5% of patients reached HbA1c <7%. Body weight increased from 65.2 kg to 65.5 kg, which was not significant. Meanwhile, there was significant increase in the mean daily insulin dose from 16.9 IU at baseline to 24.5 IU at month 6 (P < 0.001). Overall, 17.6% of patients experienced at least one hypoglycemic event. Conclusion: In a real-world setting, the initiation of basal insulin is an effective and well-tolerated treatment option in Korean patients with T2DM who are failing to meet targets with OHA therapy. © 2015 Korean Diabetes Association.
DOI
10.4093/dmj.2015.39.6.481
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의학전문대학원 > 의학과 > Journal papers
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