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Associations of matrix metalloproteinase (MMP)-8; MMP-9; and their inhibitor, tissue inhibitor of metalloproteinase-1, with obesity-related biomarkers in apparently healthy adolescent boys

Title
Associations of matrix metalloproteinase (MMP)-8; MMP-9; and their inhibitor, tissue inhibitor of metalloproteinase-1, with obesity-related biomarkers in apparently healthy adolescent boys
Authors
Shin Y.H.Kim K.E.Lee Y.-J.Nam J.-H.Hong Y.M.Shin H.-J.
Ewha Authors
홍영미
SCOPUS Author ID
홍영미scopus
Issue Date
2014
Journal Title
Korean Journal of Pediatrics
ISSN
1738-1061JCR Link
Citation
vol. 57, no. 12, pp. 526 - 532
Keywords
AdolescentAlanine aminotransferaseMatrix metalloproteinasesOverweightTissue inhibitor of metalloproteinase
Publisher
Korean Pediatric Society
Indexed
SCOPUS; KCI scopus
Abstract
Purpose: Matrix metalloproteinases (MMPs) have been implicated in atherosclerosis, and therefore, are considered risk factors for metabolic dysfunction in adults. However, there is little data regarding circulating levels of MMPs and tissue inhibitors of MMPs (TIMPs) in the general adolescent population with regard to obesity-related biomarkers. In the present study, we determined the associations of MMP-8, MMP-9, and TIMP-1 levels and MMP-8/TIMP-1 and MMP-9/TIMP-1 ratios with obesity-related biomarkers in apparently healthy adolescent boys. Methods: We measured MMP and TIMP concentrations in plasma samples using the enzyme-linked immunosorbent assay and analyzed their associations with obesity-related biomarkers, such as liver enzymes and lipid profiles, in a sample of 91 Korean boys aged 13–14 years who participated in a general health check-up. Results: The mean age of the boys was 13.8±0.3 years; 72 boys were normal weight and 19 were overweight/obese. The Pearson correlation coefficients revealed a significant correlation between MMP-8 and aspartate aminotransferase (r=0.217, P =0.039) and alanine aminotransferase (r=0.250, P =0.017) and between TIMP-1 and aspartate aminotransferase (r=0.267, P =0.011). In a multivariate linear regression analysis, serum alanine aminotransferase was positively associated with the MMP-8 level. There were no significant differences in the MMP-8, MMP-9, and TIMP-1 levels or MMP-8/TIMP-1 and MMP-9/TIMP-1 ratios between control and overweight/obese subjects. Conclusion: We found a significant association between the MMP-8 level and alanine aminotransferase in the apparently healthy adolescent boys. These findings indicate that there may be a pathophysiological mechanism underlying the relationship between MMP-8 and liver enzymes in young adolescents. © 2014 by The Korean Pediatric Society.
DOI
10.3345/kjp.2014.57.12.526
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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