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dc.contributor.author편욱범-
dc.date.accessioned2016-08-29T12:08:44Z-
dc.date.available2016-08-29T12:08:44Z-
dc.date.issued2016-
dc.identifier.issn0167-5273-
dc.identifier.otherOAK-16116-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/230918-
dc.description.abstractBackground/objectives: The effect of aspirin and clopidogrel in a fixed-dose combination (FDC) on platelet function was compared with separate formulations in patients that had undergone percutaneous coronary intervention (PCI) with drug-eluting stent (DES). Methods: This was a phase IV, prospective, multicenter, single-arm, non-inferiority study. Patients that had taken aspirin 100 mg and clopidogrel 75 mg once daily as separate formulations for > 6 months after PCI with DES were enrolled, and then switched to an aspirin/clopidogrel FDC once-daily for 4 weeks. Platelet reactivity was determined using the VerifyNow® P2Y12 assay at baseline (immediately prior to switching) and 4 weeks later. Results: A total of 648 patients (the full-analysis population; age, 63.6 ± 9.0 years; male, 76.5%) finished the study, and 565 (the per-protocol population) completed without protocol violations. In the per-protocol population, the % inhibitions of P2Y12 and ARU were not significantly different between baseline and after 4 weeks of FDC treatment (29.2 ± 20.0% to 29.0 ± 19.9%, P = 0.708; 445.1 ± 69.2 to 446.2 ± 63.0, P = 0.799, respectively) and the difference in P2Y12 inhibition observed did not exceed the predetermined limit of non-inferiority (95% CI, - 0.9 to 1.3). In the full-analysis population, the % inhibitions of P2Y12, PRU, and ARU were not significantly changed after 4 weeks of FDC treatment. Conclusions This study demonstrates that the efficacy of platelet inhibition by an aspirin/clopidogrel FDC was not inferior to that of separate aspirin and clopidogrel formulations in patients that had undergone PCI with DES. © 2015, Elsevier Ireland Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherElsevier Ireland Ltd-
dc.subjectAspirin-
dc.subjectClopidogrel-
dc.subjectFixed-dose combination-
dc.subjectPlatelet function-
dc.titleComparative effect on platelet function of a fixed-dose aspirin and clopidogrel combination versus separate formulations in patients with coronary artery disease: A phase IV, multicenter, prospective, 4-week non-inferiority trial-
dc.typeArticle-
dc.relation.volume202-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage331-
dc.relation.lastpage335-
dc.relation.journaltitleInternational Journal of Cardiology-
dc.identifier.doi10.1016/j.ijcard.2015.09.024-
dc.identifier.wosidWOS:000366161500080-
dc.identifier.scopusid2-s2.0-84960155503-
dc.author.googleOh P.C.-
dc.author.googleAhn T.-
dc.author.googleKim D.W.-
dc.author.googleHong B.-K.-
dc.author.googleKim D.-S.-
dc.author.googleKwan J.-
dc.author.googleChoi C.U.-
dc.author.googleYang Y.-M.-
dc.author.googleBae J.H.-
dc.author.googleJung K.T.-
dc.author.googleChoi W.G.-
dc.author.googleJeon D.W.-
dc.author.googleCho D.K.-
dc.author.googlePyun W.B.-
dc.author.googleCha K.S.-
dc.author.googleCha T.-J.-
dc.author.googleChun K.J.-
dc.author.googleKim Y.D.-
dc.author.googleKim B.S.-
dc.author.googleKim D.-I.-
dc.author.googleKim T.I.-
dc.contributor.scopusid편욱범(6508352922)-
dc.date.modifydate20180329112529-
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