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(E)-4-(3,4-dimethoxyphenyl)but-3-en-1-ol enhances melanogenesis through increasing upstream stimulating factor-1-mediated tyrosinase expression

Title
(E)-4-(3,4-dimethoxyphenyl)but-3-en-1-ol enhances melanogenesis through increasing upstream stimulating factor-1-mediated tyrosinase expression
Authors
Park J.Chung H.Bang S.H.Han A.-R.Seo E.-K.Chang S.E.Kang D.-H.Oh E.-S.
Ewha Authors
강덕희오억수서은경
SCOPUS Author ID
강덕희scopus; 오억수scopus; 서은경scopus
Issue Date
2015
Journal Title
PLoS ONE
ISSN
1932-6203JCR Link
Citation
vol. 10, no. 11
Publisher
Public Library of Science
Indexed
SCIE; SCOPUS WOS scopus
Abstract
We investigated the potential melanogenic effect of compounds from Zingiber cassumunar Roxb. Our data revealed that chloroform-soluble extract of Z. cassumunar enhanced melanin synthesis in B16F10 melanoma cells. Among the components of the chloroform extract, (E)-4-(3,4-dimethoxyphenyl)but-3-en-1-ol (DMPB) increased melanogenesis in both B16F10 cells and human primary melanocytes. In B16F10 cells, DMPB enhanced the activation of ERK and p38, and the level of tyrosinase. Although the level of microphthalmia-associated transcription factor was unchanged in DMPB-treated B16F10 cells, DMPB increased levels and nuclear localization of upstream stimulating factor-1 (USF1). Consistently, DMPB-mediated melanin synthesis was diminished in USF1-knockdown cells. Furthermore, DMPB induced hyperpigmentation in brown Guinea pigs in vivo. Together, these data suggest that DMPB may promote melanin synthesis via USF1 dependent fashion and could be used as a clinical therapeutic agent against hypopigmentation-associated diseases. © 2015 Park et al This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI
10.1371/journal.pone.0141988
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의학전문대학원 > 의학과 > Journal papers
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