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Increased epicardial adipose tissue thickness in type 2 diabetes mellitus and Obesity

Title
Increased epicardial adipose tissue thickness in type 2 diabetes mellitus and Obesity
Authors
SongD.K.HongY.S.LeeH.OhJ.-Y.SungY.-A.KimY.
Ewha Authors
성연아홍영선김유경오지영이혜진
SCOPUS Author ID
성연아scopus; 홍영선scopus; 김유경scopus; 오지영scopus; 이혜진scopus
Issue Date
2015
Journal Title
Diabetes and Metabolism Journal
ISSN
2233-6079JCR Link
Citation
vol. 39, no. 5, pp. 405 - 413
Keywords
Adipose tissueDiabetes mellitus, type 2Obesity
Publisher
Korean Diabetes Association
Indexed
SCOPUS; KCI scopus
Abstract
Background: Epicardial adipose tissue (EAT) is suggested to play an important role in the progression of metabolic syndrome. We aimed to establish a simple method to measure EAT and examine the differences in EAT thickness according to the presence of type 2 diabetes mellitus or obesity. Methods: A total of 94 patients (42.6% type 2 diabetes mellitus, 53.2% obese, mean age 61±13) who underwent multidetector computed tomography were enrolled. Thickness of EAT was measured on the parasternal short and horizontal long axis view. Epicardial fat area (EFA) was measured at the level of left main coronary artery (LMCA). Results: All EAT thicknesses were correlated with EFA at the LMCA level (r=0.235 to 0.613, all Ps < 0.05), and EAT thickness in the left atrioventricular groove (LAVG) had the highest correlation coefficient (r=0.613). EFA, and EAT thicknesses in the LAVG and the left ventricular apex were higher in the group with type 2 diabetes mellitus than in the group without type 2 diabetes mellitus when adjusted only for body mass index. When adjusted only for type 2 diabetes mellitus, EFA, and EAT thicknesses in the LAVG and the right atrioventricular groove were higher in obese group than in nonobese group. Conclusion: In conclusion, EAT thickness can be easily measured and represent EFA. EAT thickness, especially in LAVG, was higher in groups with type 2 diabetes mellitus and obesity independently. These findings implicate that EAT thickness may be a useful indicator for type 2 diabetes mellitus and obesity. © 2015 Korean Diabetes Association.
DOI
10.4093/dmj.2015.39.5.405
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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