Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신정아 | * |
dc.date.accessioned | 2016-08-29T12:08:40Z | - |
dc.date.available | 2016-08-29T12:08:40Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 0014-4835 | * |
dc.identifier.other | OAK-15962 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/230884 | - |
dc.description.abstract | Retinitis Pigmentosa (RP) is an inherited disorder that may lead to blindness. In the rhodopsin S334ter-line-3 rat model of RP, the death of rods induces spatial rearrangement of cones into regular ring mosaics. Using this model, we discovered that the ring mosaics are restored to a homogeneous distribution upon application of tissue inhibitor of metalloproteinase-1 (TIMP-1). In this study, we further investigated the cone migration and spatial distribution of second-order neurons and their connections to cones in the presence or absence of TIMP-1 using immunohistochemistry to identify retinal neurons and their connections with cones. M-opsin cell bodies and their outer segments were evaluated to determine whether TIMP-1 delays the degeneration of outer segments of cones. We observed that during cone rearrangement into ring mosaics in RP retina, dendritic processes of second-order neurons undergo remodeling to maintain their synaptic connections with the cones in the rings. TIMP-1 treatment induced the cones to rearrange and dendritic processes of second-order neurons to return to a more homogeneous spatial distribution. In addition, TIMP-1 treatment protected the outer segments of cones at later stages of retinal degeneration. Our findings clearly demonstrate that despite their dramatic spatial rearrangement, cones and second-order neuron processes maintain their synaptic connections before and after TIMP-1 treatment. © 2015 Elsevier Ltd. | * |
dc.language | English | * |
dc.publisher | Academic Press | * |
dc.subject | Bipolar cell | * |
dc.subject | Cone mosaic | * |
dc.subject | Cone outer segment | * |
dc.subject | Horizontal cell | * |
dc.subject | Retinitis pigmentosa | * |
dc.subject | Synaptic protein | * |
dc.subject | Tissue inhibitor of metalloproteinase-1(TIMP-1) | * |
dc.title | TIMP-1 affects the spatial distribution of dendritic processes of second-order neurons in a rat model of Retinitis Pigmentosa | * |
dc.type | Article | * |
dc.relation.volume | 140 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 41 | * |
dc.relation.lastpage | 52 | * |
dc.relation.journaltitle | Experimental Eye Research | * |
dc.identifier.doi | 10.1016/j.exer.2015.08.005 | * |
dc.identifier.wosid | WOS:000364259700006 | * |
dc.identifier.scopusid | 2-s2.0-84956613472 | * |
dc.author.google | Shin J.-A. | * |
dc.author.google | Eom Y.S. | * |
dc.author.google | Yu W.-Q. | * |
dc.author.google | Grzywacz N.M. | * |
dc.author.google | Craft C.M. | * |
dc.author.google | Lee E.-J. | * |
dc.contributor.scopusid | 신정아(56559179800) | * |
dc.date.modifydate | 20240222145329 | * |