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A Standardized Extract of Rhus verniciflua Stokes Protects Wistar Rats Against Lipopolysaccharide-Induced Acute Inflammation

Title
A Standardized Extract of Rhus verniciflua Stokes Protects Wistar Rats Against Lipopolysaccharide-Induced Acute Inflammation
Authors
Moon J.E.Shin J.-H.Kwon O.Kim J.Y.
Ewha Authors
권오란
SCOPUS Author ID
권오란scopus
Issue Date
2015
Journal Title
Journal of Medicinal Food
ISSN
1096-620XJCR Link
Citation
vol. 18, no. 11, pp. 1223 - 1230
Keywords
FustinInflammationLipopolysaccharideRhus verniciflua stokes extract
Publisher
Mary Ann Liebert Inc.
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Rhus verniciflua stokes (RVS) (Anacardiaceae) has been traditionally used as a folk remedy for gastritis, several cancers, and various metabolic diseases. The present study evaluated the anti-inflammatory effect of RVS extract standardized to fustin content using lipopolysaccharide (LPS)-stimulated rats. The rats were randomly divided into six groups and intragastrically administered 0, 100, 250, or 500mg/kg body weight (bw) of RVS or 15mg/kg bw of fustin for 14 days. LPS was intraperitoneally injected 18h before sacrifice. The nitric oxide levels of RVS extract in either the serum or liver were significantly decreased compared to the LPS-treated rats (P<.05). The treatment with the RVS extract also blunted the rise of malondialdehyde levels in the liver (P<.05). The administration of RVS extract and fustin significantly prevented the elevation of interleukin 6 cytokine, iNOS, and COX-2 mRNA expression in the liver. Inflammatory cell infiltration was also significantly attenuated by the RVS extract or fustin supplementation. These results suggest that our standardized RVS extract has preventive effects on inflammatory reactions. © Copyright 2015, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition 2015.
DOI
10.1089/jmf.2014.3411
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
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