View : 787 Download: 0
Extracellular vesicle-derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression
- Title
- Extracellular vesicle-derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression
- Authors
- Kim J.-H.; Jeun E.-J.; Hong C.-P.; Kim S.-H.; Jang M.S.; Lee E.-J.; Moon S.J.; Yun C.H.; Im S.-H.; Jeong S.-G.; Park B.-Y.; Kim K.-T.; Seoh J.-Y.; Kim Y.-K.; Oh S.-J.; Ham J.-S.; Yang B.-G.; Jang M.H.
- Ewha Authors
- 서주영; 김윤근
- SCOPUS Author ID
- 서주영; 김윤근
- Issue Date
- 2016
- Journal Title
- Journal of Allergy and Clinical Immunology
- ISSN
- 0091-6749
- Citation
- Journal of Allergy and Clinical Immunology vol. 137, no. 2, pp. 507 - 516
- Keywords
- Bifidobacterium longum; extracellular vesicle; family 5 extracellular solute-binding protein; Food allergy; mast cells; ovalbumin; probiotics
- Publisher
- Mosby Inc.
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background The incidence of food allergies has increased dramatically during the last decade. Recently, probiotics have been studied for the prevention and treatment of allergic disease. Objective We examined whether Bifidobacterium longum KACC 91563 and Enterococcus faecalis KACC 91532 have the capacity to suppress food allergies. Methods B longum KACC 91563 and E faecalis KACC 91532 were administered to BALB/c wild-type mice, in which food allergy was induced by using ovalbumin and alum. Food allergy symptoms and various immune responses were assessed. Results B longum KACC 91563, but not E faecalis KACC 91532, alleviated food allergy symptoms. Extracellular vesicles of B longum KACC 91563 bound specifically to mast cells and induced apoptosis without affecting T-cell immune responses. Furthermore, injection of family 5 extracellular solute-binding protein, a main component of extracellular vesicles, into mice markedly reduced the occurrence of diarrhea in a mouse food allergy model. Conclusion B longum KACC 91563 induces apoptosis of mast cells specifically and alleviates food allergy symptoms. Accordingly, B longum KACC 91563 and family 5 extracellular solute-binding protein exhibit potential as therapeutic approaches for food allergies. © 2015 American Academy of Allergy, Asthma & Immunology.
- DOI
- 10.1016/j.jaci.2015.08.016
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML