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Extracellular vesicle-derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression

Title
Extracellular vesicle-derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression
Authors
Kim J.-H.Jeun E.-J.Hong C.-P.Kim S.-H.Jang M.S.Lee E.-J.Moon S.J.Yun C.H.Im S.-H.Jeong S.-G.Park B.-Y.Kim K.-T.Seoh J.-Y.Kim Y.-K.Oh S.-J.Ham J.-S.Yang B.-G.Jang M.H.
Ewha Authors
서주영김윤근
SCOPUS Author ID
서주영scopus; 김윤근scopusscopus
Issue Date
2016
Journal Title
Journal of Allergy and Clinical Immunology
ISSN
0091-6749JCR Link
Citation
vol. 137, no. 2, pp. 507 - 516
Keywords
Bifidobacterium longumextracellular vesiclefamily 5 extracellular solute-binding proteinFood allergymast cellsovalbuminprobiotics
Publisher
Mosby Inc.
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background The incidence of food allergies has increased dramatically during the last decade. Recently, probiotics have been studied for the prevention and treatment of allergic disease. Objective We examined whether Bifidobacterium longum KACC 91563 and Enterococcus faecalis KACC 91532 have the capacity to suppress food allergies. Methods B longum KACC 91563 and E faecalis KACC 91532 were administered to BALB/c wild-type mice, in which food allergy was induced by using ovalbumin and alum. Food allergy symptoms and various immune responses were assessed. Results B longum KACC 91563, but not E faecalis KACC 91532, alleviated food allergy symptoms. Extracellular vesicles of B longum KACC 91563 bound specifically to mast cells and induced apoptosis without affecting T-cell immune responses. Furthermore, injection of family 5 extracellular solute-binding protein, a main component of extracellular vesicles, into mice markedly reduced the occurrence of diarrhea in a mouse food allergy model. Conclusion B longum KACC 91563 induces apoptosis of mast cells specifically and alleviates food allergy symptoms. Accordingly, B longum KACC 91563 and family 5 extracellular solute-binding protein exhibit potential as therapeutic approaches for food allergies. © 2015 American Academy of Allergy, Asthma & Immunology.
DOI
10.1016/j.jaci.2015.08.016
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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