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Uveitis as an important ocular sign to help early diagnosis in Kawasaki disease

Title
Uveitis as an important ocular sign to help early diagnosis in Kawasaki disease
Authors
ChoiH.S.LeeS.B.KwonJ.H.KimSohnS.J.HongY.M.
Ewha Authors
홍영미김혜순손세정권정현
SCOPUS Author ID
홍영미scopus; 김혜순scopus; 손세정scopus
Issue Date
2015
Journal Title
Korean Journal of Pediatrics
ISSN
1738-1061JCR Link
Citation
vol. 58, no. 10, pp. 374 - 379
Keywords
Brain natriuretic peptideKawasaki diseaseUveitis
Publisher
Korean Pediatric Society
Indexed
SCOPUS; KCI scopus
Abstract
Purpose: Incomplete Kawasaki disease (KD) is frequently associated with delayed diagnosis and treatment. Delayed diagnosis leads to increasing risk of coronary artery aneurysm. Anterior uveitis is an important ocular signs of KD. The purpose of this study was to assess differences in laboratory findings, including echocardiographic measurements, clinical characteristics such as fever duration and treatment responses between KD patients with and those without uveitis. Methods: We conducted a prospective study with 110 KD patients from January 2008 to June 2013. The study group (n=32, KD with uveitis) was compared with the control group (n=78, KD without uveitis). Laboratory data were obtained from each patient including complete blood count (CBC), erythrocyte sedimentation rate (ESR), platelet count, and level of alanine aminotransferase, aspartate aminotransferase, serum total protein, albumin, C-reactive protein (CRP), and N-terminal probrain natriuretic peptide (NT-pro BNP). Echocardiographic measurements and intravenous immunoglobulin responses were compared between the two groups. Results: The incidence of uveitis was 29.0%. Neutrophil counts and patient age were higher in the uveitis group than in the control group. ESR and CRP level were slightly increased in the uveitis group compared with the control group, but the difference between the two groups was not significant. No significant differences in coronary arterial complication and treatment responses were observed between the two groups. Conclusion: Uveitis is an important ocular sign in the diagnosis of incomplete KD. It is significantly associated with patient age and neutrophil count. © 2015 by The Korean Pediatric Society.
DOI
10.3345/kjp.2015.58.10.374
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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